5-(3-Fluorophenyl)-2-methyl-pyridin

Base Information

• Chemical Name: 5-(3-Fluorophenyl)-2-methyl-pyridin
• CAS No.: 713143-67-0
• Molecular Formula: C12H10 F N
• Molecular Weight: 187.217
• Hs Code.: 2933399990
• Mol file: 713143-67-0.mol

Synonyms:5-(3-Fluorophenyl)-2-methyl-pyridin

Chemical Property of 5-(3-Fluorophenyl)-2-methyl-pyridin

Chemical Property:

• Vapor Pressure: 0.00508mmHg at 25°C
• Refractive Index: 1.551
• Boiling Point: 284.5°C at 760 mmHg
• PKA: 5.05±0.11(Predicted)
• Flash Point: 125.9°C
• PSA: 12.89000
• Density: 1.111g/cm³
• LogP: 3.19610
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

96% ^*data from raw suppliers

5-(3-Fluorophenyl)-2-methylpyridine 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(3-Fluorophenyl)-2-methyl-pyridin

There total 3 articles about 5-(3-Fluorophenyl)-2-methyl-pyridin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3-fluorophenylboronic acid (768-35-4) + (6-methylpyridin-3-yl)trifluoromethanesulfonate (111770-91-3) → 5-(3-fluorophenyl)-2-methylpyridine (713143-67-0)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 120 ℃; for 22h;

Reference yield: 96.0%

5-bromo-2-methylpyridine (3430-13-5) + 3-fluorophenylboronic acid (768-35-4) → 5-(3-fluorophenyl)-2-methylpyridine (713143-67-0)

Guidance literature:

With potassium phosphate; {2-[2-(di(2-naphthyloxy)phosphinoxy)-3,5-bis(tert-butyl)phenyl]-4,6-bis(tert-butyl)phenoxy}di(2-naphthyloxy)phosphine; (1,5-cyclo-octadiene) nickel complexes; In toluene; at 80 ℃; for 6h;

Reference yield:

5-Hydroxy-2-methylpyridine (1121-78-4) → 5-(3-fluorophenyl)-2-methylpyridine (713143-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 1.5 h / 0 °C

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 22 h / 120 °C

With pyridine; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; toluene;

upstream raw materials:

5-bromo-2-methylpyridine

3-fluorophenylboronic acid

(6-methylpyridin-3-yl)trifluoromethanesulfonate

5-Hydroxy-2-methylpyridine

Downstream raw materials:

[5-(3-fluorophenyl)-pyridin-2-ylmethyl]-phosphonic acid diethyl ester

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