2-METHYL-5-PYRIDINETRIFLUOROMETHANESULF&

Base Information

• Chemical Name: 2-METHYL-5-PYRIDINETRIFLUOROMETHANESULF&
• CAS No.: 111770-91-3
• Molecular Formula: C7H6 F3 N O3 S
• Molecular Weight: 241.191
• Hs Code.: 2933399090
• Mol file: 111770-91-3.mol

Synonyms:Methanesulfonicacid, trifluoro-, 6-methyl-3-pyridinyl ester (9CI); 2-Methyl-5-[(trifluoromethyl)sulfonyloxy]pyridine;3-[[(Trifluoromethyl)sulfonyl]oxy]-6-methylpyridine; 6-Methylpyridin-3-yltrifluoromethanesulfonate

Chemical Property of 2-METHYL-5-PYRIDINETRIFLUOROMETHANESULF&

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: n20/D 1.442(lit.)
• Boiling Point: 268.5°Cat760mmHg
• Flash Point: 116.2°C
• PSA: 64.64000
• Density: 1.504g/cm³
• LogP: 2.69920
• Sensitive.: Moisture Sensitive

Purity/Quality:

98%min ^*data from raw suppliers

2-Methyl-5-pyridinetrifluoromethanesulfonate 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-5-PYRIDINETRIFLUOROMETHANESULF&

There total 8 articles about 2-METHYL-5-PYRIDINETRIFLUOROMETHANESULF& which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

5-Hydroxy-2-methylpyridine (1121-78-4) + trifluoromethylsulfonic anhydride (358-23-6) → (6-methylpyridin-3-yl)trifluoromethanesulfonate (111770-91-3)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1016/j.bmc.2006.08.044

Reference yield: 95.0%

5-Hydroxy-2-methylpyridine (1121-78-4) + trifluoromethanesulfonic acid anhydride (1025373-45-8) → (6-methylpyridin-3-yl)trifluoromethanesulfonate (111770-91-3)

Guidance literature:

5-Hydroxy-2-methylpyridine; trifluoromethanesulfonic acid anhydride; With pyridine; In dichloromethane; at 0 ℃; for 1.5h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield: 87.0%

5-Hydroxy-2-methylpyridine (1121-78-4) + N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) → (6-methylpyridin-3-yl)trifluoromethanesulfonate (111770-91-3)

Guidance literature:

With triethylamine; In dichloromethane; for 18h; Ambient temperature;

DOI:10.1021/jo00237a029

upstream raw materials:

5-Hydroxy-2-methylpyridine

N,N-phenylbistrifluoromethane-sulfonimide

trifluoromethylsulfonic anhydride

trifluoromethanesulfonic acid anhydride

Refernces

• 1、 Tartaggia, Stefano,Caporale, Andrea,Fontana, Francesco,Stabile, Paolo,Castellin, Andrea,De Lucchi, Ottorino. "A convenient synthesis of the key intermediate of selective COX-2 inhibitor Etoricoxib". . p. 18544 - 18549. Retrieved 2013/10/21.
• 2、 -. "Improved process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib". Page/Page column 7. . Retrieved 2012/09/22.