2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynylphosphinic acid

Base Information

Chemical Name:2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynylphosphinic acid
CAS No.:952661-08-4
Molecular Formula:C₁₄H₁₅O₅P
Molecular Weight:294.244
Hs Code.:

Synonyms:2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynylphosphinic acid

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Chemical Property of 2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynylphosphinic acid

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Technology Process of 2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynylphosphinic acid

There total 1 articles about 2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: C₆H₉PO₄

: 70-11-1
α-bromoacetophenone

: 952661-08-4
2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynylphosphinic acid

Guidance literature:: With triethylamine; In ethyl acetate; at 20 ℃; for 6h;
DOI:10.1021/jo071081l

Reference yield: 41.0%

: 952661-08-4
2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynylphosphinic acid

: 952661-09-5
methyl (2S)-2-{[(benzyloxy)carbonyl](tert-butoxycarbonyl)amino}-5-oxopentanoate

: 952661-10-8
(2S)-1-[(benzyloxy)carbonyl]-5-(methoxycarbonyl)tetrahydro-1H-pyrrol-2-yl{2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynyl}phosphinic acid

Guidance literature:: methyl (2S)-2-{[(benzyloxy)carbonyl](tert-butoxycarbonyl)amino}-5-oxopentanoate; With acetic acid; trifluoroacetic acid; at 20 ℃; for 0.5h;

2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynylphosphinic acid; With acetic acid; acetyl chloride; trifluoroacetic acid; at 20 ℃; for 5h; Further stages.;
DOI:10.1021/jo071081l

Reference yield:

: 952661-08-4
2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynylphosphinic acid

: 952703-85-4
1-benzyl 2-methyl (2S)-5-((1-adamantyloxy){2-[(2-oxo-2-phenylethoxy)carbonyl]-4-pentynyl}phosphoryl)tetrahydro-1H-pyrrole-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: TFA; AcOH / 0.5 h / 20 °C

1.2: 41 percent / AcCl; AcOH; TFA / 5 h / 20 °C

2.1: 44 percent / Ag₂O / CHCl₃ / 3 h / Heating

With acetic acid; trifluoroacetic acid; silver(l) oxide; In chloroform;
DOI:10.1021/jo071081l