Technology Process of <β-<3,4-(dimethoxy)phenyl>cyclohex-2-enyl>acetohydroxamic acid
There total 6 articles about <β-<3,4-(dimethoxy)phenyl>cyclohex-2-enyl>acetohydroxamic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 66 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 16 h / Heating
3: 89 percent / NaBH4 / ethanol / 12 h / -20 °C
4: 76 percent / pyridine / 18 h / Ambient temperature
5: 1.) lithium isopropylcyclohexylamide, HMPA, 2.) tert-butyldimethylchlorosilane / 1.) THF, -78 deg C, 5 min, 2.) reflux, 3 h
6: 1.) SOCl2, 2.) NH2OH*HCl, Na2CO3 / 1.) benzene, DMF, reflux, 2 h, 2.) diethyl ether
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; Perbenzoic acid; hydroxylamine hydrochloride; sodium carbonate; lithium cyclohexylisopropylamide; tert-butyldimethylsilyl chloride;
In
tetrachloromethane; ethanol;
DOI:10.1021/jo00346a028
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / NaBH4 / ethanol / 12 h / -20 °C
2: 76 percent / pyridine / 18 h / Ambient temperature
3: 1.) lithium isopropylcyclohexylamide, HMPA, 2.) tert-butyldimethylchlorosilane / 1.) THF, -78 deg C, 5 min, 2.) reflux, 3 h
4: 1.) SOCl2, 2.) NH2OH*HCl, Na2CO3 / 1.) benzene, DMF, reflux, 2 h, 2.) diethyl ether
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; sodium carbonate; lithium cyclohexylisopropylamide; tert-butyldimethylsilyl chloride;
In
ethanol;
DOI:10.1021/jo00346a028
- Guidance literature:
-
Multi-step reaction with 5 steps
2: 89 percent / NaBH4 / ethanol / 12 h / -20 °C
3: 76 percent / pyridine / 18 h / Ambient temperature
4: 1.) lithium isopropylcyclohexylamide, HMPA, 2.) tert-butyldimethylchlorosilane / 1.) THF, -78 deg C, 5 min, 2.) reflux, 3 h
5: 1.) SOCl2, 2.) NH2OH*HCl, Na2CO3 / 1.) benzene, DMF, reflux, 2 h, 2.) diethyl ether
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; thionyl chloride; hydroxylamine hydrochloride; sodium carbonate; lithium cyclohexylisopropylamide; tert-butyldimethylsilyl chloride;
In
ethanol;
DOI:10.1021/jo00346a028
