N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-(4-trifluoromethyl-phenyl)-acetamide

Base Information

Chemical Name:N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-(4-trifluoromethyl-phenyl)-acetamide
CAS No.:745062-85-5
Molecular Formula:C₂₃H₂₆F₃NO₃
Molecular Weight:421.46
Hs Code.:

<i>N</i>-(5,6-dimethoxy-indan-2-yl)-<i>N</i>-propyl-2-(4-trifluoromethyl-phenyl)-acetamide

Synonyms:N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-(4-trifluoromethyl-phenyl)-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-(4-trifluoromethyl-phenyl)-acetamide

Chemical Property:

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Technology Process of N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-(4-trifluoromethyl-phenyl)-acetamide

There total 6 articles about N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-(4-trifluoromethyl-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 162751-96-4
5,6-dimethoxy-2-(N-propylamino)indan

: 745062-85-5
N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-(4-trifluoromethyl-phenyl)-acetamide

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm010145w

Reference yield:

: 2107-69-9
5,6-dimethoxy-1-indanone

: 745062-85-5
N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-(4-trifluoromethyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / n-butylnitrite; conc. aq. HCl / methanol / 0.5 h / 40 °C

2: H₂; H₂SO₄ / 10percent Pd/C / acetic acid / 7 h / 2585.81 Torr

3: 100 percent / diethylcyanophosphonate; Et₃N / CH₂Cl₂ / 3 h / 20 °C

4: 85 percent / LiAlH₄ / tetrahydrofuran / 5 h

5: 99 percent / diethylcyanophosphonate; Et₃N / CH₂Cl₂ / 24 h / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; n-Butyl nitrite; diethyl cyanophosphonate; sulfuric acid; hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; dichloromethane; acetic acid;
DOI:10.1021/jm010145w

Reference yield:

: 2107-85-9
5,6-dimethoxy-indan-1,2-dione-2-oxime

: 745062-85-5
N-(5,6-dimethoxy-indan-2-yl)-N-propyl-2-(4-trifluoromethyl-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: H₂; H₂SO₄ / 10percent Pd/C / acetic acid / 7 h / 2585.81 Torr

2: 100 percent / diethylcyanophosphonate; Et₃N / CH₂Cl₂ / 3 h / 20 °C

3: 85 percent / LiAlH₄ / tetrahydrofuran / 5 h

4: 99 percent / diethylcyanophosphonate; Et₃N / CH₂Cl₂ / 24 h / 20 °C

With lithium aluminium tetrahydride; diethyl cyanophosphonate; sulfuric acid; hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jm010145w