cyanomethyl 4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:cyanomethyl 4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1449664-95-2
Molecular Formula:C₂₄H₂₆N₆O₂
Molecular Weight:430.509
Hs Code.:

Synonyms:cyanomethyl 4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyanomethyl 4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of cyanomethyl 4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

There total 9 articles about cyanomethyl 4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 607373-83-1
2-chloro-4-methoxy-5-nitro-pyridine

: 1449664-95-2
cyanomethyl 4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrahydrofuran / 2 h / 20 °C

2.1: iron; acetic acid / 1 h / 50 - 80 °C

3.1: 4 h / 100 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

5.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.33 h / 0 °C

5.2: 0.5 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

7.1: dichloromethane / 1 h / 20 °C

7.2: 96 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; iron; acetic acid; trifluoroacetic acid; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1449506-75-5
N-(2-ethyl-4-(1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridine-amine

: 107-16-4
glycolonitrile

: 1449664-95-2
cyanomethyl 4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: bis(trichloromethyl) carbonate; glycolonitrile; In dichloromethane; at 20 ℃; for 1h;

N-(2-ethyl-4-(1,2,3,6-tetrahydropyridin-4-yl)phenyl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridine-amine; In dichloromethane; at 20 ℃; for 96h;

Reference yield:

: 45762-41-2
4-bromo-2-ethylaniline

: 1449664-95-2
cyanomethyl 4-(3-ethyl-4-(methyl(1-methyl-1H-imidazo[4,5-c]pyridin-6-yl)amino)phenyl)-5,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,4-dioxane; water / 18 h / Reflux

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; sodium t-butanolate / 1,4-dioxane / 1.5 h / 100 °C / Inert atmosphere

3.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide / 0.33 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 24 h / 20 °C

5.1: dichloromethane / 1 h / 20 °C

5.2: 96 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hexamethyldisilazane; caesium carbonate; trifluoroacetic acid; sodium t-butanolate; XPhos; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;