5-{5’-O-dimethoxytrityl-3’-O-2-cyanoethoxy(diisopropylamino)phosphino-2’-deoxy-D-ribofuranosyl}-2-phenoxyacetylaminopyridine

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Chemical Name:5-{5’-O-dimethoxytrityl-3’-O-2-cyanoethoxy(diisopropylamino)phosphino-2’-deoxy-D-ribofuranosyl}-2-phenoxyacetylaminopyridine
CAS No.:1449482-16-9
Molecular Formula:C₄₈H₅₅N₄O₈P
Molecular Weight:846.96
Hs Code.:

Synonyms:5-{5’-O-dimethoxytrityl-3’-O-2-cyanoethoxy(diisopropylamino)phosphino-2’-deoxy-D-ribofuranosyl}-2-phenoxyacetylaminopyridine

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Chemical Property of 5-{5’-O-dimethoxytrityl-3’-O-2-cyanoethoxy(diisopropylamino)phosphino-2’-deoxy-D-ribofuranosyl}-2-phenoxyacetylaminopyridine

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Technology Process of 5-{5’-O-dimethoxytrityl-3’-O-2-cyanoethoxy(diisopropylamino)phosphino-2’-deoxy-D-ribofuranosyl}-2-phenoxyacetylaminopyridine

There total 4 articles about 5-{5’-O-dimethoxytrityl-3’-O-2-cyanoethoxy(diisopropylamino)phosphino-2’-deoxy-D-ribofuranosyl}-2-phenoxyacetylaminopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1449482-14-7
5-(5’-O-dimethoxytrityl-2’-deoxy-D-ribofuranosyl)-2-phenoxyacetylaminopyridine

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1449482-16-9
5-{5’-O-dimethoxytrityl-3’-O-2-cyanoethoxy(diisopropylamino)phosphino-2’-deoxy-D-ribofuranosyl}-2-phenoxyacetylaminopyridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3.5h; Inert atmosphere;
DOI:10.3987/COM-12-S(N)68

Reference yield:

: 1β-(6-aminopyridin-3-yl)-1,2-dideoxy-D-ribofuranose

: 1449482-16-9
5-{5’-O-dimethoxytrityl-3’-O-2-cyanoethoxy(diisopropylamino)phosphino-2’-deoxy-D-ribofuranosyl}-2-phenoxyacetylaminopyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 13 h / 0 - 20 °C / Inert atmosphere

2: pyridine / 10 h / 0 - 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

4: pyridine / 10 h / 0 - 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-12-S(N)68

Reference yield:

: 1449482-10-3
5-[3’,5’-di-O-tert-butyldimethylsilyl-(2’-deoxy-D-ribofuranosyl)]-2-phenoxyacetylaminopyridine

: 1449482-16-9
5-{5’-O-dimethoxytrityl-3’-O-2-cyanoethoxy(diisopropylamino)phosphino-2’-deoxy-D-ribofuranosyl}-2-phenoxyacetylaminopyridine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 8 h / 0 - 20 °C / Inert atmosphere

2: pyridine / 10 h / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.3987/COM-12-S(N)68