ethoxycarbonylmethyl 2-[2'-(p-methoxyphenyl)ethynyl]phenyl ether

Base Information

• Chemical Name: ethoxycarbonylmethyl 2-[2'-(p-methoxyphenyl)ethynyl]phenyl ether
• CAS No.: 1192031-39-2
• Molecular Formula: C₁₉H₁₈O₄
• Molecular Weight: 310.35
• Mol file: 1192031-39-2.mol

Synonyms:ethoxycarbonylmethyl 2-[2'-(p-methoxyphenyl)ethynyl]phenyl ether

Chemical Property of ethoxycarbonylmethyl 2-[2'-(p-methoxyphenyl)ethynyl]phenyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ethoxycarbonylmethyl 2-[2'-(p-methoxyphenyl)ethynyl]phenyl ether

There total 2 articles about ethoxycarbonylmethyl 2-[2'-(p-methoxyphenyl)ethynyl]phenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-([(ethoxycarbonyl)methylene]oxy)-1-iodobenzene (90794-32-4) + 4-methoxyphenylacetylen (768-60-5) → ethoxycarbonylmethyl 2-[2'-(p-methoxyphenyl)ethynyl]phenyl ether (1192031-39-2)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In acetonitrile; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2013.07.104

Reference yield:

2-Iodophenol (533-58-4) → ethoxycarbonylmethyl 2-[2'-(p-methoxyphenyl)ethynyl]phenyl ether (1192031-39-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 4 h / 20 °C / Reflux

2: copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / acetonitrile / Inert atmosphere; Reflux

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; triethylamine; In acetone; acetonitrile; 2: |Sonogashira Cross-Coupling;

DOI:10.1016/j.tet.2013.07.104

Reference yield: 94.0%

ethoxycarbonylmethyl 2-[2'-(p-methoxyphenyl)ethynyl]phenyl ether (1192031-39-2) → ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)phenoxy)acetate (1459129-16-8)

Guidance literature:

With ruthenium trichloride; sodium periodate; sodium hydrogencarbonate; magnesium sulfate; In tetrachloromethane; water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2013.07.104

upstream raw materials:

2-([(ethoxycarbonyl)methylene]oxy)-1-iodobenzene

4-methoxyphenylacetylen

2-Iodophenol

Downstream raw materials:

2-ethoxycarbonyl-3-(p-methoxybenzyl)benzofuran

ethyl 2-(2-(2-(4-methoxyphenyl)-2-oxoacetyl)phenoxy)acetate

ethyl 3-(4-methoxyphenyl)-4-oxo-4H-chromene-2-carboxylate

ethyl 3-(4-methoxybenzoyl)benzofuran-2-carboxylate