N-methyl-N-phenyl-2-(N-(2-hydroxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide

Base Information

Chemical Name:N-methyl-N-phenyl-2-(N-(2-hydroxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide
CAS No.:205694-43-5
Molecular Formula:C₂₅H₂₆N₄O₄
Molecular Weight:446.506
Hs Code.:

Synonyms:N-methyl-N-phenyl-2-(N-(2-hydroxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methyl-N-phenyl-2-(N-(2-hydroxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide

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Technology Process of N-methyl-N-phenyl-2-(N-(2-hydroxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide

There total 5 articles about N-methyl-N-phenyl-2-(N-(2-hydroxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 205694-42-4
N-methyl-N-phenyl-2-(N-(2-benzyloxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide

: 205694-43-5
N-methyl-N-phenyl-2-(N-(2-hydroxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; ethyl acetate; for 2.5h; under 760 Torr;
DOI:10.1248/cpb.46.434

Reference yield:

: 20012-63-9
o-(benzyloxy)aniline

: 205694-43-5
N-methyl-N-phenyl-2-(N-(2-hydroxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 39 percent / DMAP, EDC*HCl / CH₂Cl₂ / 12 h / Ambient temperature

2: 1.) NaH / 1.) THF, 55 deg C, 1 h, 2.) THF, RT, 2 h

3: 98 percent / TFA / CH₂Cl₂ / 0.5 h

4: 84 percent / tetrahydrofuran / 0.25 h / Ambient temperature

5: 97 percent / H₂ / 5percent Pd/C / methanol; ethyl acetate / 2.5 h / 760 Torr

With dmap; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.46.434

Reference yield:

: 183180-09-8
N-(2-benzyloxyphenyl)-2-(N-tert-butoxycarbonylamino)acetamide

: 205694-43-5
N-methyl-N-phenyl-2-(N-(2-hydroxyphenyl)-N-{2-[3-(3-methylphenyl)ureido]acetyl}amino)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, 55 deg C, 1 h, 2.) THF, RT, 2 h

2: 98 percent / TFA / CH₂Cl₂ / 0.5 h

3: 84 percent / tetrahydrofuran / 0.25 h / Ambient temperature

4: 97 percent / H₂ / 5percent Pd/C / methanol; ethyl acetate / 2.5 h / 760 Torr

With hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.46.434