1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester

Base Information

• Chemical Name: 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester
• CAS No.: 1207070-76-5
• Molecular Formula: C₂₀H₂₄N₂O₄
• Molecular Weight: 356.422
• Mol file: 1207070-76-5.mol

Synonyms:1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester

Chemical Property of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester

Chemical Property:

Purity/Quality:

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Technology Process of 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester

There total 9 articles about 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid (26171-23-3) + 2-methoxy-phenol (90-05-1) → 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester (1207070-76-5)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 30 ℃;

DOI:10.1021/op900284w

Reference yield: 60.0%

isopropyl alcohol (67-63-0,8013-70-5) + Tolmetin glycine amide (87344-05-6) → 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester (1207070-76-5)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 30 ℃;

DOI:10.1021/op900284w

Reference yield:

N-Methylpyrrole (96-54-8) → 1-methyl-5-p-toluoylpyrrole-2-acetamidoacetic acid isopropyl alcohol ester (1207070-76-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: dichloromethane / 1 h / -10 - 0 °C

1.2: 0.5 h / -10 - 0 °C / pH 10

2.1: hydrazine hydrate; potassium hydroxide / water / 5 h / 100 °C

3.1: potassium carbonate / dichloromethane / 3 h / 30 °C

4.1: o-xylene / 24 h / 145 °C

5.1: sodium hydroxide / methanol; water / 2 h / 30 °C

6.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 30 °C

With potassium carbonate; benzotriazol-1-ol; hydrazine hydrate; triethylamine; dicyclohexyl-carbodiimide; potassium hydroxide; sodium hydroxide; In methanol; dichloromethane; o-xylene; water; 2.1: Wolff-Kishner reduction;

DOI:10.1021/op900284w

upstream raw materials:

N-Methylpyrrole

1-methylpyrrole-2-acetic acid

C₁₈H₂₀N₂O₄

2-(1-methyl-1H-pyrrol-2-yl)-2-oxoacetic acid