(2,4-bis(benzyloxy)-5-(1H-indol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(2,4-bis(benzyloxy)-5-(1H-indol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone
CAS No.:1609699-92-4
Molecular Formula:C₃₄H₃₃N₃O₃
Molecular Weight:531.654
Hs Code.:

Synonyms:(2,4-bis(benzyloxy)-5-(1H-indol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone

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Chemical Property of (2,4-bis(benzyloxy)-5-(1H-indol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone

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Technology Process of (2,4-bis(benzyloxy)-5-(1H-indol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone

There total 6 articles about (2,4-bis(benzyloxy)-5-(1H-indol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 109-01-3
1-methyl-piperazine

: 1609699-91-3
2,4-bis(benzyloxy)-5-(1H-indol-1-yl)benzoic acid

: 1609699-92-4
(2,4-bis(benzyloxy)-5-(1H-indol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2014.03.100

Reference yield:

: 89-86-1
4-hydroxysalicylic acid

: 1609699-92-4
(2,4-bis(benzyloxy)-5-(1H-indol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; bromine

2: thionyl chloride / 16 h / 20 °C

3: potassium carbonate / acetonitrile / 5 h / Reflux

4: copper(l) iodide; L-proline; potassium phosphate / 1,4-dioxane / 110 °C / Microwave irradiation; Inert atmosphere; Sealed tube

5: lithium hydroxide; water / deuteromethanol / 2 h / 100 °C

6: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With potassium phosphate; copper(l) iodide; thionyl chloride; water; bromine; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; L-proline; lithium hydroxide; In 1,4-dioxane; dichloromethane; deuteromethanol; acetonitrile;
DOI:10.1016/j.bmcl.2014.03.100

Reference yield:

: 98437-43-5
methyl 2-chloro-3,4-dihydroxybenzoate

: 1609699-92-4
(2,4-bis(benzyloxy)-5-(1H-indol-1-yl)phenyl)(4-methylpiperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 5 h / Reflux

2: copper(l) iodide; L-proline; potassium phosphate / 1,4-dioxane / 110 °C / Microwave irradiation; Inert atmosphere; Sealed tube

3: lithium hydroxide; water / deuteromethanol / 2 h / 100 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With potassium phosphate; copper(l) iodide; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; L-proline; lithium hydroxide; In 1,4-dioxane; dichloromethane; deuteromethanol; acetonitrile;
DOI:10.1016/j.bmcl.2014.03.100