98437-43-5

Basic information

• Product Name: 5-BROMO-2,4-DIHYDROXYBENZOIC ACID METHYL ESTER
• Synonyms: 5-BROMO-2,4-DIHYDROXYBENZOIC ACID METHYL ESTER;Methyl 5-broMo-2,4-dihydroxybenzoate;Benzoic acid, 5-broMo-2,4-dihydroxy-, Methyl ester
• CAS NO: 98437-43-5
• Molecular Formula: C₈H₇BrO₄
• Molecular Weight: 247.04
• Product Categories: Aromatic Esters
• Mol File: 98437-43-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 384.15°C at 760 mmHg
• Flash Point: 186.128°C
• Appearance: /
• Density: 1.76g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.623
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-BROMO-2,4-DIHYDROXYBENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2,4-DIHYDROXYBENZOIC ACID METHYL ESTER(98437-43-5)
• EPA Substance Registry System: 5-BROMO-2,4-DIHYDROXYBENZOIC ACID METHYL ESTER(98437-43-5)

Safety Data

• Hazardous Substances Data: 98437-43-5(Hazardous Substances Data)

Usage

General Description

5-Bromo-2,4-dihydroxybenzoic acid methyl ester is a chemical compound with the molecular formula C8H7BrO4. It is a methyl ester derivative of 5-bromo-2,4-dihydroxybenzoic acid and is commonly used as a building block in organic synthesis. 5-BROMO-2,4-DIHYDROXYBENZOIC ACID METHYL ESTER has a white to off-white appearance and is sparingly soluble in water. It is used in various research and industrial applications, including as a precursor in the synthesis of pharmaceuticals and other organic compounds. Additionally, it has potential applications in the development of new materials and chemical processes. Overall, 5-bromo-2,4-dihydroxybenzoic acid methyl ester is a valuable compound in the field of organic chemistry and has a variety of potential uses in research and industry.

InChI:InChI=1/C8H7BrO4/c1-13-8(12)4-2-5(9)7(11)3-6(4)10/h2-3,10-11H,1H3

Upstream product

• 7355-22-8 5-bromo-4-hydroxysalicylic acid 
• 684-93-5 1-methyl-1-nitrosourea 
• 67-56-1 methanol 
• 89-86-1 4-hydroxysalicylic acid 

Downstream Products

• 99853-34-6 5-bromo-3-butyryl-2,4-dihydroxy-benzoic acid 
• 104780-38-3 5-bromo-3-butyryl-2,4-dihydroxy-benzoic acid methyl ester 
• 958253-44-6 methyl 2,4-bis(benzyloxy)-5-bromobenzoate 
• 1240325-32-9 methyl 5-bromo-2-hydroxy-4-(2-methylallyloxy)benzoate 
• 136997-68-7 Sophoraflavanone H 

Relevant articles and documents

Total Synthesis of Sophoraflavanone H and Confirmation of Its Absolute Configuration

Sophoraflavanone H (1) is a polyphenol with a hybrid-type structure containing 2,3-diaryl-2,3-dihydrobenzofuran and flavanone ring moieties. This compound and related analogues are promising leads for antimicrobial and antitumor drug development. Here we

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization

Heat shock protein 90 (HSP90) is a molecular chaperone to fold and maintain the proper conformation of many signaling proteins, especially some oncogenic proteins and mutated unstable proteins. Inhibition of HSP90 was recognized as an effective approach to simultaneously suppress several aberrant signaling pathways, and therefore it was considered as a novel target for cancer therapy. Here, by integrating several techniques including the fragment-based drug discovery method, fragment merging, computer aided inhibitor optimization, and structure-based drug design, we were able to identify a series of HSP90 inhibitors. Among them, inhibitors 13, 32, 36 and 40 can inhibit HSP90 with IC50 about 20-40 nM, which is at least 200-fold more potent than initial fragments in the protein binding assay. These new HSP90 inhibitors not only explore interactions with an under-studied subpocket, also offer new chemotypes for the development of novel HSP90 inhibitors as anticancer drugs.

TRIAZOLE DERIVATIVE AS AN HSP 90 INHIBITOR

5-[4-(2-Methylphenyl)-3-hydroxy-4H-1,2,4-triazol-5-yl]-2,4-dihydroxy-N-methyl-N-butylbenzamide is an HSP90 inhibitor and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.