98437-43-5

Usage

Uses

Used in Organic Synthesis:
5-Bromo-2,4-dihydroxybenzoic acid methyl ester is used as a building block in organic synthesis for the creation of various organic compounds. Its unique structure allows for the development of new materials and chemical processes, contributing to the advancement of organic chemistry.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 5-Bromo-2,4-dihydroxybenzoic acid methyl ester is used as a precursor in the synthesis of pharmaceuticals. Its properties make it a valuable component in the development of new drugs and medicinal compounds, potentially leading to innovative treatments and therapies.
Used in Research Applications:
5-Bromo-2,4-dihydroxybenzoic acid methyl ester is utilized in research settings to explore its chemical properties and potential applications. Its use in scientific studies aids in understanding its behavior in different chemical reactions and environments, further expanding the knowledge of organic chemistry.
Used in Material Development:
5-BROMO-2,4-DIHYDROXYBENZOIC ACID METHYL ESTER has potential applications in the development of new materials, where its unique structure and properties can be leveraged to create innovative and improved materials for various industries.
Overall, 5-Bromo-2,4-dihydroxybenzoic acid methyl ester is a versatile and valuable compound in the field of organic chemistry, with a wide range of applications in research, pharmaceuticals, and material development.

InChI:InChI=1/C8H7BrO4/c1-13-8(12)4-2-5(9)7(11)3-6(4)10/h2-3,10-11H,1H3

Upstream product

• 7355-22-8 5-bromo-4-hydroxysalicylic acid 
• 89-86-1 4-hydroxysalicylic acid 
• 67-56-1 methanol 
• 684-93-5 1-methyl-1-nitrosourea 

Downstream Products

• 99853-34-6 5-bromo-3-butyryl-2,4-dihydroxy-benzoic acid 
• 104780-38-3 5-bromo-3-butyryl-2,4-dihydroxy-benzoic acid methyl ester 
• 99853-35-7 5-bromo-2,4-dihydroxy-3-propionyl-benzoic acid methyl ester 
• 108488-42-2 5-bromo-2,4-bis-propionyloxy-benzoic acid methyl ester 
• 958253-44-6 methyl 2,4-bis(benzyloxy)-5-bromobenzoate 
• 136997-68-7 Sophoraflavanone H 

Relevant academic research and scientific papers

Total Synthesis of Sophoraflavanone H and Confirmation of Its Absolute Configuration

Sophoraflavanone H (1) is a polyphenol with a hybrid-type structure containing 2,3-diaryl-2,3-dihydrobenzofuran and flavanone ring moieties. This compound and related analogues are promising leads for antimicrobial and antitumor drug development. Here we

Phenyl 1, 2 - isoxazole or phenyl 1, 2 - pyrazole compound and use thereof (by machine translation)

The invention discloses the following formula of phenyl 1, 2 - different oxazole or 1, 2 - pyrazole compounds with use. Through the biological activity tests show that, the compound inhibiting heat shock protein 90 activity. Therefore, the invention phenyl 1, 2 - different oxazole or 1, 2 - pyrazole compounds can be used as a heat shock protein 90 inhibitor for the treatment of cancer. (by machine translation)

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization

Heat shock protein 90 (HSP90) is a molecular chaperone to fold and maintain the proper conformation of many signaling proteins, especially some oncogenic proteins and mutated unstable proteins. Inhibition of HSP90 was recognized as an effective approach to simultaneously suppress several aberrant signaling pathways, and therefore it was considered as a novel target for cancer therapy. Here, by integrating several techniques including the fragment-based drug discovery method, fragment merging, computer aided inhibitor optimization, and structure-based drug design, we were able to identify a series of HSP90 inhibitors. Among them, inhibitors 13, 32, 36 and 40 can inhibit HSP90 with IC50 about 20-40 nM, which is at least 200-fold more potent than initial fragments in the protein binding assay. These new HSP90 inhibitors not only explore interactions with an under-studied subpocket, also offer new chemotypes for the development of novel HSP90 inhibitors as anticancer drugs.

Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1- ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design

Inhibitors of the molecular chaperone heat shock protein 90 (Hsp90) are currently generating significant interest in clinical development as potential treatments for cancer. In a preceding publication (DOI: 10.1021/jm100059d) we describe Astex's approach to screening fragments against Hsp90 and the subsequent optimization of two hits into leads with inhibitory activities in the low nanomolar range. This paper describes the structure guided optimization of the 2,4-dihydroxybenzamide lead molecule 1 and details some of the drug discovery strategies employed in the identification of AT13387 (35), which has progressed through preclinical development and is currently being tested in man.

TRIAZOLE DERIVATIVE AS AN HSP 90 INHIBITOR

5-[4-(2-Methylphenyl)-3-hydroxy-4H-1,2,4-triazol-5-yl]-2,4-dihydroxy-N-methyl-N-butylbenzamide is an HSP90 inhibitor and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

1,3-DIHYDROISOINDOLE DERIVATIVES

Novel 1,3-dihydroisoindole derivatives of the formula (I), in which R1-R3 have the meanings indicated in claim 1, areHSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

TRIAZOLE DERIVATIVES II

Novel triazole derivatives of the formula (I) in which R1—R6 and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY

The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound.