(+)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylalaninamide

Base Information

Chemical Name:(+)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylalaninamide
CAS No.:936628-14-7
Molecular Formula:C₁₇H₂₆N₂O₃
Molecular Weight:306.405
Hs Code.:

(+)-(S)-N<sup>2</sup>-(tert-butoxycarbonyl)-N<sup>1</sup>-(2,6-dimethylphenyl)-N<sup>1</sup>-methylalaninamide

Synonyms:(+)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylalaninamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylalaninamide

Chemical Property:

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Technology Process of (+)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylalaninamide

There total 4 articles about (+)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 86516-39-4
(-)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)alaninamide

: 74-88-4
methyl iodide

: 936628-14-7
(+)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylalaninamide

Guidance literature:: With barium dihydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm061078e

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: 936628-14-7
(+)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylalaninamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; triethylamine / CHCl₃ / 6 h / Heating

2: 80 percent / Ba(OH)2*8H₂O / H₂O; dimethylformamide / 12 h / 20 °C

With barium dihydroxide; 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; triethylamine; In chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm061078e

Reference yield:

: 73371-96-7
2-<<(tert-butoxycarbonyl)oxy>imino>-2-phenylacetonitrile

: 936628-14-7
(+)-(S)-N²-(tert-butoxycarbonyl)-N¹-(2,6-dimethylphenyl)-N¹-methylalaninamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / H₂O; dioxane / 20 °C

2: 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; triethylamine / CHCl₃ / 6 h / Heating

3: 80 percent / Ba(OH)2*8H₂O / H₂O; dimethylformamide / 12 h / 20 °C

With barium dihydroxide; 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline; triethylamine; In 1,4-dioxane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/jm061078e