Technology Process of (2S,3S,6R)-3-Benzyloxy-6-((Z)-dodeca-2,11-dienyl)-2-methyl-piperidine-1-carboxylic acid methyl ester
There total 16 articles about (2S,3S,6R)-3-Benzyloxy-6-((Z)-dodeca-2,11-dienyl)-2-methyl-piperidine-1-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: NaH / dimethylformamide; benzene / 80 °C
2: 96 percent / Lawesson's reagent / tetrahydrofuran / Heating
3: 83 percent / PPh3, Et3N / acetonitrile / Heating
4: 99 percent / NaBH3CN, TFA / CH2Cl2 / 0 °C
5: H2 / Pd(OH)2 / methanol
6: K2CO3 / CH2Cl2; H2O
7: 92 percent / Super-Hydride
8: (COCl)2, DMSO, Et3N
9: n-BuLi / tetrahydrofuran
With
Lawessons reagent; n-butyllithium; oxalyl dichloride; hydrogen; sodium hydride; lithium triethylborohydride; sodium cyanoborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; trifluoroacetic acid;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo990397t
- Guidance literature:
-
Multi-step reaction with 15 steps
1: 88 percent / baker's yeast / H2O
2: 98 percent / Huenig base / CHCl3 / Heating
3: 96 percent / Super-Hydride / tetrahydrofuran / 0 °C
4: 95 percent / n-Bu3P, pyridine
5: 95 percent / Raney Ni (W-4) / ethanol
6: conc. HCl / methanol
7: NaH / dimethylformamide; benzene / 80 °C
8: 96 percent / Lawesson's reagent / tetrahydrofuran / Heating
9: 83 percent / PPh3, Et3N / acetonitrile / Heating
10: 99 percent / NaBH3CN, TFA / CH2Cl2 / 0 °C
11: H2 / Pd(OH)2 / methanol
12: K2CO3 / CH2Cl2; H2O
13: 92 percent / Super-Hydride
14: (COCl)2, DMSO, Et3N
15: n-BuLi / tetrahydrofuran
With
Lawessons reagent; pyridine; hydrogenchloride; n-butyllithium; baker's yeast; oxalyl dichloride; tributylphosphine; Raney Ni (W-4); hydrogen; sodium hydride; lithium triethylborohydride; sodium cyanoborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid;
palladium dihydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo990397t
- Guidance literature:
-
Multi-step reaction with 10 steps
1: conc. HCl / methanol
2: NaH / dimethylformamide; benzene / 80 °C
3: 96 percent / Lawesson's reagent / tetrahydrofuran / Heating
4: 83 percent / PPh3, Et3N / acetonitrile / Heating
5: 99 percent / NaBH3CN, TFA / CH2Cl2 / 0 °C
6: H2 / Pd(OH)2 / methanol
7: K2CO3 / CH2Cl2; H2O
8: 92 percent / Super-Hydride
9: (COCl)2, DMSO, Et3N
10: n-BuLi / tetrahydrofuran
With
Lawessons reagent; hydrogenchloride; n-butyllithium; oxalyl dichloride; hydrogen; sodium hydride; lithium triethylborohydride; sodium cyanoborohydride; potassium carbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; trifluoroacetic acid;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1021/jo990397t
