(2S,3S,4R)-2-hexacosanoylamido-(2,3,4-tri-O-benzyl-6-deoxy-6-azido-α-D-galactopyranosyloxy)octadecane-3,4-diol

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Chemical Name:(2S,3S,4R)-2-hexacosanoylamido-(2,3,4-tri-O-benzyl-6-deoxy-6-azido-α-D-galactopyranosyloxy)octadecane-3,4-diol
CAS No.:424823-30-3
Molecular Formula:C₇₁H₁₁₆N₄O₈
Molecular Weight:1153.72
Hs Code.:

Synonyms:(2S,3S,4R)-2-hexacosanoylamido-(2,3,4-tri-O-benzyl-6-deoxy-6-azido-α-D-galactopyranosyloxy)octadecane-3,4-diol

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Chemical Property of (2S,3S,4R)-2-hexacosanoylamido-(2,3,4-tri-O-benzyl-6-deoxy-6-azido-α-D-galactopyranosyloxy)octadecane-3,4-diol

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Technology Process of (2S,3S,4R)-2-hexacosanoylamido-(2,3,4-tri-O-benzyl-6-deoxy-6-azido-α-D-galactopyranosyloxy)octadecane-3,4-diol

There total 7 articles about (2S,3S,4R)-2-hexacosanoylamido-(2,3,4-tri-O-benzyl-6-deoxy-6-azido-α-D-galactopyranosyloxy)octadecane-3,4-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (2S,3S,4R)-2-(N-hexacosanoylamino)-3,4-di-O-benzoyl-1-O-(2,3,4-tri-O-benzyl-6-azide-α-D-galactopyranosyl)-1,3,4-octadecanetriol

: 424823-30-3
(2S,3S,4R)-2-hexacosanoylamido-(2,3,4-tri-O-benzyl-6-deoxy-6-azido-α-D-galactopyranosyloxy)octadecane-3,4-diol

Guidance literature:: With sodium methylate; In methanol; dichloromethane; at 20 ℃; for 12h; pH=9;
DOI:10.1016/j.carres.2019.107840

Reference yield: 81.0%

: 424823-22-3
Hexacosanoic acid [(1S,2S,3R)-1-((2S,3R,4S,5S,6R)-6-azidomethyl-3,4,5-tris-benzyloxy-tetrahydro-pyran-2-yloxymethyl)-2,3-bis-(tert-butyl-dimethyl-silanyloxy)-heptadecyl]-amide

: 424823-30-3
(2S,3S,4R)-2-hexacosanoylamido-(2,3,4-tri-O-benzyl-6-deoxy-6-azido-α-D-galactopyranosyloxy)octadecane-3,4-diol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1021/ol025565+

Reference yield:

: 1-O-acetyl-6-azido-2,3,4-tri-O-benzyl-6-deoxy-α,β-D-galactopyranose

: 424823-30-3
(2S,3S,4R)-2-hexacosanoylamido-(2,3,4-tri-O-benzyl-6-deoxy-6-azido-α-D-galactopyranosyloxy)octadecane-3,4-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / HF*pyridine / pyridine; toluene / 6 h / 0 °C

2: 44 percent / molecular sieves 4 Angstroem; AgClO₄; SnCl₂ / tetrahydrofuran / 2 h / 0 - 20 °C

3: 81 percent / TBAF / tetrahydrofuran / 1.5 h / 20 °C

With 4 A molecular sieve; tetrabutyl ammonium fluoride; silver perchlorate; pyridine hydrogenfluoride; tin(ll) chloride; In tetrahydrofuran; pyridine; toluene;
DOI:10.1021/ol025565+