N⁴-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine

Base Information

• Chemical Name: N⁴-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine
• CAS No.: 389063-49-4
• Molecular Formula: C₄₅H₄₅N₃O₁₃
• Molecular Weight: 835.865

Synonyms:N⁴-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine

Chemical Property of N⁴-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine

Chemical Property:

Purity/Quality:

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Technology Process of N⁴-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine

There total 4 articles about N⁴-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + N4-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-β-D-ribofuranosyl]cytosine (389063-45-0) → N4-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine (389063-49-4)

Guidance literature:

With pyridine; at 20 ℃; for 2h;

DOI:10.1002/1522-2675(20010815)84:8<2387::AID-HLCA2387>3.0.CO;2-F

Reference yield:

1,2,3-tri-O-acetyl-D-erythrofuranose (186495-36-3) → N4-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine (389063-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / SnCl₄ / 1,2-dichloro-ethane / 72 h / 0 °C

2: 70 percent / Bu₄NF*3H₂O / tetrahydrofuran / 0.25 h / 20 °C

3: 87 percent / pyridine / 2 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; tin(IV) chloride; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1002/1522-2675(20010815)84:8<2387::AID-HLCA2387>3.0.CO;2-F

Reference yield:

1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]-N4-benzoylcytosine (69304-43-4) → N4-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-5-O-(dimethoxytrityl)-β-D-ribofuranosyl]cytosine (389063-49-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / SnCl₄ / 1,2-dichloro-ethane / 72 h / 0 °C

2: 70 percent / Bu₄NF*3H₂O / tetrahydrofuran / 0.25 h / 20 °C

3: 87 percent / pyridine / 2 h / 20 °C

With pyridine; tetrabutyl ammonium fluoride; tin(IV) chloride; In tetrahydrofuran; 1,2-dichloro-ethane;

DOI:10.1002/1522-2675(20010815)84:8<2387::AID-HLCA2387>3.0.CO;2-F

upstream raw materials:

4,4'-dimethoxytrityl chloride

N⁴-benzoyl-1-[2-O-(2,3-di-O-acetyl-β-D-erythrofuranosyl)-β-D-ribofuranosyl]cytosine

1,2,3-tri-O-acetyl-D-erythrofuranose

1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]-N⁴-benzoylcytosine

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