69304-43-4

Usage

Uses

Used in Pharmaceutical Industry:
N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine is used as a chiral building block for the preparation of mannosylated oligoribonucleotides. These modified oligoribonucleotides can be employed as therapeutic agents, particularly in the development of antisense drugs, which target specific RNA sequences to modulate gene expression and treat various diseases.
Used in Research and Development:
In the field of research and development, N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine serves as a valuable compound for studying the synthesis and properties of mannosylated oligoribonucleotides. This allows scientists to explore their potential applications in gene regulation, drug delivery, and other areas of biotechnology.
Used in Diagnostic Applications:
N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine can also be utilized in the development of diagnostic tools, such as molecular probes and biosensors, that rely on the specific recognition and binding of mannosylated oligoribonucleotides to target molecules. This can aid in the detection and monitoring of various diseases and conditions.
Overall, N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine is a versatile and valuable compound with a range of potential applications in the pharmaceutical, research, and diagnostic industries. Its unique structure and properties make it an essential component in the development of innovative therapies and technologies.

Upstream product

• 18043-71-5 1,1,3,3-tetraisopropyldisiloxane 
• 13089-48-0 N₄-benzoylcytidine 
• 69304-42-3 3',5'-O-[(1,1,3,3-tetraisopropyl)-1,3-disiloxanediyl]cytidine 
• 93-97-0 benzoic acid anhydride 
• 98-88-4 benzoyl chloride 
• 1054642-81-7 N-[2-Oxo-1-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-trimethylsilanyloxy-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1,2-dihydro-pyrimidin-4-yl]-benzamide 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 65-46-3 CYTIDINE 

Downstream Products

• 169687-75-6 N⁴-benzoyl-1-[3,5-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-β-D-ribofuranosyl]cytosine 
• 389063-40-5 N⁴-benzoyl-1-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2-O-(2,3,4-tri-O-acetyl-β-D-ribopyranosyl)-β-D-ribofuranosyl]cytosine 
• 933063-81-1 1-{2-O-[(2-acetoxyethoxy)methyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl}-N⁴-benzoylcytosine 
• 933063-83-3 1-{2-O-[(3-acetoxypropoxy)methyl]-3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl}-N⁴-benzoylcytosine 
• 112317-77-8 syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine 
• 112317-72-3 anti-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)-cytidine 
• 557789-95-4 syn-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite) 
• 557789-96-5 anti-N⁴-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tetrahydrofuran-2-yl)cytidine 3'-(2-cyanoethyl diisopropylphosphoramidite) 
• 87865-87-0 syn-N⁴-benzoyl-2'-O-(tetrahydrofuran-2-yl)cytidine 
• 87865-84-7 anti-N⁴-benzoyl-2'-O-(tetrahydrofuran-2-yl)cytidine 
• 929896-79-7 C₃₆H₅₀N₄O₁₀Si₂ 
• 929896-82-2 N⁴-benzoyl-2'-O-[[(4-nitrobenzyl)oxy]methyl]cytidine 
• 929896-86-6 C₄₅H₄₂N₄O₁₁ 
• 929896-90-2 C₅₄H₅₉N₆O₁₂P 

Relevant academic research and scientific papers

Synthesis method for azvudine

The invention discloses a synthesis method for azvudine. The method comprises the following steps of carrying out a hydroxyl substitution reaction on a compound 4 and an iodine elementary substance toobtain a compound 5, carrying out an elimination reaction on an iodo group in the compound 5 to obtain a compound 6, reacting the compound 6 with azide under the catalysis of ICl to obtain a compound7, carrying out an iodine substitution reaction on the compound 7 and carboxylic acid to obtain a compound 8, and carrying out an amino and hydroxyl deprotection reaction on the compound 8 to obtaina compound 9, namely the alzvudine. Compared with an existing synthesis method, the synthesis method has the advantages of short synthesis route, shortened reaction time, mild reaction conditions andeasily controlled reaction process, can be used for preparing the alzvudine with the lower cost, and has a very good application prospect.

MODIFIED NUCLEOSIDE PHOSPHORAMIDITES

The present disclosure relates to compounds and compositions containing 5'-phosphoramidite nucleoside monomers of formulae (I) and (II), and methods of making and use, wherein the substituents are as defined in the appended claims.

High-yield synthesis method of sofosbuvir and sofosbuvir prepared with method

The invention relates to a high-yield synthesis method of sofosbuvir and sofosbuvir prepared with the method. The method comprises steps as follows: (a) cytidine and benzoic anhydride are dissolved in a first organic solvent for a reaction; TIDPSCl2 is ad

NUCLEOSIDE PHOSPHONATE DERIVATIVES

The present invention discloses compounds of formula (I) or (II), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit, preventing or treating abnormal cellular proliferation and/or a viral infection, particularly by HIV, HCV o

An azidomethyl protective group in the synthesis of oligoribonucleotides by the phosphotriester method

A rapid and effective method of an automatic oligoribonucleotide synthesis alternative to the phosphoramidite one was developed. This method is based on the phosphotriester approach to internucleotide bond formation under intramolecular O-nucleophilic cat

Preparation of zwitterionic ribonucleoside phosphoramidites for solid-phase siRNA synthesis

(Chemical Equation Presented) RNA oligomers, carrying 2′-O-modified nucleosides, proved to be extremely useful in different antisense strategies, including RNAi. The 2′-O-alkyl modification, carrying an amino functionality, deserves special attention due

The 4-(N-dichloroacetyl-N-methylamino)benzyloxymethyl group for 2′-hydroxyl protection of ribonucleosides in the solid-phase synthesis of oligoribonucleotides

(Chemical Equation Presented) Emerging RNA-based technologies for controlling gene expression have triggered a high demand for synthetic oligoribonucleotides and have motivated the development of ribonucleoside phosphoramidites that would exhibit coupling

Semisynthesis of 3′(2′)-O-(aminoacyl)-tRNA derivatives as ribosomal substrate

An efficient synthesis of (3′-terminally) 3′(2′)-O- aminoacylated pCpA derivatives is described, which could lead to the production of (aminoacyl)-tRNAs following T4 RNA ligase mediated ligation. The tetrahydrofuranyl (thf) group was used as a permanent p

Assessment of 4-nitrogenated benzyloxymethyl groups for 2′-Hydroxyl protection in solid-phase RNA synthesis

The search for a 2′-OH protecting group that would impart ribonucleoside phosphoramidites with coupling kinetics and coupling efficiencies comparable to those of deoxyribonucleoside phosphoramidites led to an assessment of 2′-0-(4-nitrogenated benzyloxy)m

Synthesis of RNA using 2′-O-DTM protection

tert-Butyldithiomethyl (DTM), a novel hydroxyl protecting group, cleavable under reductive conditions, was developed and applied for the protection of 2′-OH during solid-phase RNA synthesis. This function is compatible with all standard protecting groups used in oligonucleotide synthesis, and allows for fast and high-yield synthesis of RNA. Oligonucleotides containing the 2′-O-DTM groups can be easily deprotected under the mildest possible aqueous and homogeneous conditions. The preserved 5′-O-DMTr function can be used for high-throughput cartridge RNA purification. Copyright