69304-43-4 Usage
Description
N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine is a chiral building block with a unique structure that features a cytidine core, a benzoyl group at the N4 position, and a 1,1,3,3-tetraisopropyl-1,3-disiloxanediyl protecting group at the 3' and 5' positions. N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine is characterized by its ability to serve as a key intermediate in the synthesis of mannosylated oligoribonucleotides, which have potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine is used as a chiral building block for the preparation of mannosylated oligoribonucleotides. These modified oligoribonucleotides can be employed as therapeutic agents, particularly in the development of antisense drugs, which target specific RNA sequences to modulate gene expression and treat various diseases.
Used in Research and Development:
In the field of research and development, N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine serves as a valuable compound for studying the synthesis and properties of mannosylated oligoribonucleotides. This allows scientists to explore their potential applications in gene regulation, drug delivery, and other areas of biotechnology.
Used in Diagnostic Applications:
N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine can also be utilized in the development of diagnostic tools, such as molecular probes and biosensors, that rely on the specific recognition and binding of mannosylated oligoribonucleotides to target molecules. This can aid in the detection and monitoring of various diseases and conditions.
Overall, N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine is a versatile and valuable compound with a range of potential applications in the pharmaceutical, research, and diagnostic industries. Its unique structure and properties make it an essential component in the development of innovative therapies and technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 69304-43-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,3,0 and 4 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 69304-43:
(7*6)+(6*9)+(5*3)+(4*0)+(3*4)+(2*4)+(1*3)=134
134 % 10 = 4
So 69304-43-4 is a valid CAS Registry Number.
69304-43-4Relevant articles and documents
Synthesis method for azvudine
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Paragraph 0082-0084, (2020/11/22)
The invention discloses a synthesis method for azvudine. The method comprises the following steps of carrying out a hydroxyl substitution reaction on a compound 4 and an iodine elementary substance toobtain a compound 5, carrying out an elimination reaction on an iodo group in the compound 5 to obtain a compound 6, reacting the compound 6 with azide under the catalysis of ICl to obtain a compound7, carrying out an iodine substitution reaction on the compound 7 and carboxylic acid to obtain a compound 8, and carrying out an amino and hydroxyl deprotection reaction on the compound 8 to obtaina compound 9, namely the alzvudine. Compared with an existing synthesis method, the synthesis method has the advantages of short synthesis route, shortened reaction time, mild reaction conditions andeasily controlled reaction process, can be used for preparing the alzvudine with the lower cost, and has a very good application prospect.
High-yield synthesis method of sofosbuvir and sofosbuvir prepared with method
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Paragraph 0030, (2016/11/07)
The invention relates to a high-yield synthesis method of sofosbuvir and sofosbuvir prepared with the method. The method comprises steps as follows: (a) cytidine and benzoic anhydride are dissolved in a first organic solvent for a reaction; TIDPSCl2 is ad
An azidomethyl protective group in the synthesis of oligoribonucleotides by the phosphotriester method
Efimov,Aralov,Fedunin,Klykov,Chakhmakhcheva
scheme or table, p. 250 - 253 (2010/04/06)
A rapid and effective method of an automatic oligoribonucleotide synthesis alternative to the phosphoramidite one was developed. This method is based on the phosphotriester approach to internucleotide bond formation under intramolecular O-nucleophilic cat