(2-(2-amino-7-fluoro-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Base Information

Chemical Name:(2-(2-amino-7-fluoro-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone
CAS No.:1319194-61-0
Molecular Formula:C₂₅H₂₇FN₄O₂
Molecular Weight:434.513
Hs Code.:

Synonyms:(2-(2-amino-7-fluoro-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

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Chemical Property of (2-(2-amino-7-fluoro-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

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Technology Process of (2-(2-amino-7-fluoro-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

There total 5 articles about (2-(2-amino-7-fluoro-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309366-09-3
(2-bromo-3-methylphenyl)(pyrrolidin-1-yl)methanone

: 2-amino-7-fluoro-3-morpholinoquinolin-6-ylboronic acid

: 1319194-61-0
(2-(2-amino-7-fluoro-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; at 140 ℃; for 0.25h; microwave irradiation; Inert atmosphere; Sealed vessel;

Reference yield:

: 213382-45-7
5-bromo-4-fluoro-2-nitro-benzaldehyde

: 1319194-61-0
(2-(2-amino-7-fluoro-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 10% Pt/activated carbon / dichloromethane / 24 h / 20 °C

2.1: potassium hydroxide; water / dimethyl sulfoxide / 16.5 h / 80 °C

2.2: 20 °C

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 0.5 h / 125 °C / microwave irradiation; Sealed vessel; Inert atmosphere

4.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.25 h / 140 °C / microwave irradiation; Inert atmosphere; Sealed vessel

With potassium phosphate; water; hydrogen; potassium acetate; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 10% Pt/activated carbon; XPhos; In 1,4-dioxane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 315188-30-8
2-amino-5-bromo-4-fluorobenzaldehyde

: 1319194-61-0
(2-(2-amino-7-fluoro-3-morpholinoquinolin-6-yl)-3-methylphenyl)(pyrrolidin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / dimethyl sulfoxide / 16.5 h / 80 °C

1.2: 20 °C

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 0.5 h / 125 °C / microwave irradiation; Sealed vessel; Inert atmosphere

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.25 h / 140 °C / microwave irradiation; Inert atmosphere; Sealed vessel

With potassium phosphate; water; potassium acetate; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; XPhos; In 1,4-dioxane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;