Technology Process of C20H24N2O3
There total 7 articles about C20H24N2O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(S)-tert-butyl 2-(1-hydroxy-3-phenylpropan-2-ylamino)phenylcarbamate;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 0.75h;
With
triethylamine;
In
dichloromethane;
at -78 ℃;
for 1h;
DOI:10.1055/s-0033-1340837
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 - 80 °C
2.1: thionyl chloride / 0 °C
3.1: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C
4.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 2585.81 Torr / Inert atmosphere
5.1: sodium hydrogencarbonate / ethanol / 1 h / 0 - 20 °C
6.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C
6.2: 1 h / -78 °C
With
lithium borohydride; thionyl chloride; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; potassium carbonate; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
6.1: |Swern Oxidation / 6.2: |Swern Oxidation;
DOI:10.1055/s-0033-1340837
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C
2.1: palladium 10% on activated carbon; hydrogen / methanol / 1 h / 2585.81 Torr / Inert atmosphere
3.1: sodium hydrogencarbonate / ethanol / 1 h / 0 - 20 °C
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C
4.2: 1 h / -78 °C
With
lithium borohydride; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; dimethyl sulfoxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane;
4.1: |Swern Oxidation / 4.2: |Swern Oxidation;
DOI:10.1055/s-0033-1340837
