1-[4-benzyl-2-oxo-(4S)-1,3-oxazolan-3-yl]-6-benzyloxy-3-hydroxy-2-(4-methoxybenzyloxy)-(2S,3R)-hexan-1-one

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Chemical Name:1-[4-benzyl-2-oxo-(4S)-1,3-oxazolan-3-yl]-6-benzyloxy-3-hydroxy-2-(4-methoxybenzyloxy)-(2S,3R)-hexan-1-one
CAS No.:900783-30-4
Molecular Formula:C₃₁H₃₅NO₇
Molecular Weight:533.621
Hs Code.:

Synonyms:1-[4-benzyl-2-oxo-(4S)-1,3-oxazolan-3-yl]-6-benzyloxy-3-hydroxy-2-(4-methoxybenzyloxy)-(2S,3R)-hexan-1-one

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Chemical Property of 1-[4-benzyl-2-oxo-(4S)-1,3-oxazolan-3-yl]-6-benzyloxy-3-hydroxy-2-(4-methoxybenzyloxy)-(2S,3R)-hexan-1-one

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Technology Process of 1-[4-benzyl-2-oxo-(4S)-1,3-oxazolan-3-yl]-6-benzyloxy-3-hydroxy-2-(4-methoxybenzyloxy)-(2S,3R)-hexan-1-one

There total 3 articles about 1-[4-benzyl-2-oxo-(4S)-1,3-oxazolan-3-yl]-6-benzyloxy-3-hydroxy-2-(4-methoxybenzyloxy)-(2S,3R)-hexan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 5470-84-8
4-benzyloxybutanal

: 139462-27-4,118949-49-8
(4S)-3-[1-oxo-2-(4-methoxybenzyloxy)ethyl]-4-benzyl-2-oxazolidinone

: 900783-30-4
1-[4-benzyl-2-oxo-(4S)-1,3-oxazolan-3-yl]-6-benzyloxy-3-hydroxy-2-(4-methoxybenzyloxy)-(2S,3R)-hexan-1-one

Guidance literature:: Multistep reaction;
DOI:10.1016/j.tetasy.2006.03.024

Reference yield:

: 4541-14-4
4-benzyloxy-butan-1-ol

: 900783-30-4
1-[4-benzyl-2-oxo-(4S)-1,3-oxazolan-3-yl]-6-benzyloxy-3-hydroxy-2-(4-methoxybenzyloxy)-(2S,3R)-hexan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; 1: Swern oxidation;
DOI:10.1016/j.tetasy.2006.03.024

Reference yield:

: 100-39-0
benzyl bromide

: 900783-30-4
1-[4-benzyl-2-oxo-(4S)-1,3-oxazolan-3-yl]-6-benzyloxy-3-hydroxy-2-(4-methoxybenzyloxy)-(2S,3R)-hexan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / NaH / tetrahydrofuran / 0 - 20 °C

2: 92 percent / oxalyl chloride; DMSO; triethylamine / CH₂Cl₂ / -78 - 0 °C

With oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; 2: Swern oxidation;
DOI:10.1016/j.tetasy.2006.03.024