(3aR,7aS)-7a-Benzenesulfonyl-2-methylene-octahydro-inden-3a-ol

Base Information

• Chemical Name: (3aR,7aS)-7a-Benzenesulfonyl-2-methylene-octahydro-inden-3a-ol
• CAS No.: 74532-68-6
• Molecular Formula: C₁₆H₂₀O₃S
• Molecular Weight: 292.399
• Mol file: 74532-68-6.mol

Synonyms:(3aR,7aS)-7a-Benzenesulfonyl-2-methylene-octahydro-inden-3a-ol

Chemical Property of (3aR,7aS)-7a-Benzenesulfonyl-2-methylene-octahydro-inden-3a-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3aR,7aS)-7a-Benzenesulfonyl-2-methylene-octahydro-inden-3a-ol

There total 5 articles about (3aR,7aS)-7a-Benzenesulfonyl-2-methylene-octahydro-inden-3a-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone (74532-62-0) → (3aR,7aS)-7a-Benzenesulfonyl-2-methylene-octahydro-inden-3a-ol (74532-68-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 55 ℃; for 1h;

DOI:10.1021/ja00537a049

Reference yield:

2-phenylthiocyclohexanone (110452-14-7) → (3aR,7aS)-7a-Benzenesulfonyl-2-methylene-octahydro-inden-3a-ol (74532-68-6)

Guidance literature:

Multi-step reaction with 3 steps

1: MCPBA / CH₂Cl₂ / 0 deg C --> room temperature

2: 1.) NaH, 2.) NaI / 2) DME, 65 deg C, 36 h

3: (C₄H₉)4NF / tetrahydrofuran / 1 h / 55 °C

With tetrabutyl ammonium fluoride; sodium hydride; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00537a049

Reference yield:

2-(phenylsulphonyl)cyclohexanone (73843-10-4) → (3aR,7aS)-7a-Benzenesulfonyl-2-methylene-octahydro-inden-3a-ol (74532-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH, 2.) NaI / 2) DME, 65 deg C, 36 h

2: (C₄H₉)4NF / tetrahydrofuran / 1 h / 55 °C

With tetrabutyl ammonium fluoride; sodium hydride; sodium iodide; In tetrahydrofuran;

DOI:10.1021/ja00537a049

upstream raw materials:

2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone

2-phenylthiocyclohexanone

2-(phenylsulphonyl)cyclohexanone

cyclohexanone