2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone

Base Information

• Chemical Name: 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone
• CAS No.: 74532-62-0
• Molecular Formula: C₁₉H₂₈O₃SSi
• Molecular Weight: 364.581
• Mol file: 74532-62-0.mol

Synonyms:2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone

Chemical Property of 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone

There total 5 articles about 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-phenylthiocyclohexanone (110452-14-7) → 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone (74532-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: MCPBA / CH₂Cl₂ / 0 deg C --> room temperature

2: 1.) NaH, 2.) NaI / 2) DME, 65 deg C, 36 h

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; sodium iodide; In dichloromethane;

DOI:10.1021/ja00537a049

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone (74532-62-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) LDA / 1) THF, -78 deg C --> room temperature

2: MCPBA / CH₂Cl₂ / 0 deg C --> room temperature

3: 1.) NaH, 2.) NaI / 2) DME, 65 deg C, 36 h

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; sodium iodide; lithium diisopropyl amide; In dichloromethane;

DOI:10.1021/ja00537a049

Reference yield:

2-(trimethylsilylmethyl)prop-2-en-1-ol (81302-80-9) → 2-Benzenesulfonyl-2-(2-trimethylsilanylmethyl-allyl)-cyclohexanone (74532-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Et₃N / CH₂Cl₂ / 0 °C

2: 1.) NaH, 2.) NaI / 2) DME, 65 deg C, 36 h

With sodium hydride; triethylamine; sodium iodide; In dichloromethane;

DOI:10.1021/ja00537a049

upstream raw materials:

2-(phenylsulphonyl)cyclohexanone

3-trimethylsilyl-2-(methylsulphonyloxymethyl)prop-1-ene

2-phenylthiocyclohexanone

cyclohexanone

Downstream raw materials:

(3aR,7aS)-7a-Benzenesulfonyl-2-methylene-octahydro-inden-3a-ol