6-Oxabicyclo[3.1.0]hexane-2-carbonitrile,2-[(trimethylsilyl)oxy]-,(1R,2R,5S)-rel-(9CI)

Base Information

Chemical Name:6-Oxabicyclo[3.1.0]hexane-2-carbonitrile,2-[(trimethylsilyl)oxy]-,(1R,2R,5S)-rel-(9CI)
CAS No.:709674-10-2
Molecular Formula:C₉H₁₅NO₂Si
Molecular Weight:197.309
Hs Code.:
Mol file:709674-10-2.mol

Synonyms:6-Oxabicyclo[3.1.0]hexane-2-carbonitrile,2-[(trimethylsilyl)oxy]-,(1R,2R,5S)-rel-(9CI)

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Chemical Property of 6-Oxabicyclo[3.1.0]hexane-2-carbonitrile,2-[(trimethylsilyl)oxy]-,(1R,2R,5S)-rel-(9CI)

Chemical Property:

PSA：45.55000
LogP:1.66148

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of 6-Oxabicyclo[3.1.0]hexane-2-carbonitrile,2-[(trimethylsilyl)oxy]-,(1R,2R,5S)-rel-(9CI)

There total 4 articles about 6-Oxabicyclo[3.1.0]hexane-2-carbonitrile,2-[(trimethylsilyl)oxy]-,(1R,2R,5S)-rel-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130249-17-1,6705-52-8
2,3-epoxycyclopentanone

: 7677-24-9
trimethylsilyl cyanide

: 709674-10-2,709674-12-4
2-[(trimethylsilyl)oxy]-6-oxabicyclo[3.1.0]hexane-2-carbonitrile

: 709674-10-2
2-[(trimethylsilyl)oxy]-6-oxabicyclo[3.1.0]hexane-2-carbonitrile

Guidance literature:: With tetra-n-butylammonium cyanide; In dichloromethane; at 20 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1002/ejoc.200600239

Reference yield:

: 130249-17-1,6705-52-8
2,3-epoxycyclopentanone

: 7677-24-9
trimethylsilyl cyanide

: 709674-10-2,709674-12-4
2-[(trimethylsilyl)oxy]-6-oxabicyclo[3.1.0]hexane-2-carbonitrile

: 709674-10-2
2-[(trimethylsilyl)oxy]-6-oxabicyclo[3.1.0]hexane-2-carbonitrile

Guidance literature:: With tetra-n-butylammonium cyanide; In dichloromethane; at 20 ℃; for 1h; Title compound not separated from byproducts;
DOI:10.1002/ejoc.200600239

Reference yield:

: 930-30-3
cyclopent-2-enone

: 709674-10-2,709674-12-4
2-[(trimethylsilyl)oxy]-6-oxabicyclo[3.1.0]hexane-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrotalcite; Bu₄NBr; aq. H₂O₂ / heptane / 16 h / 45 °C

2: Bu₄NCN / CH₂Cl₂ / 1 h / 20 °C

With hydrotalcite; tetrabutylammomium bromide; dihydrogen peroxide; tetra-n-butylammonium cyanide; In n-heptane; dichloromethane;
DOI:10.1002/ejoc.200600239