methyl 4-[(aminoacetyl)amino]benzoate trifluoroacetic acid salt

Base Information

• Chemical Name: methyl 4-[(aminoacetyl)amino]benzoate trifluoroacetic acid salt
• CAS No.: 1360821-85-7
• Molecular Formula: C₂HF₃O₂*C₁₀H₁₂N₂O₃
• Molecular Weight: 322.241
• Mol file: 1360821-85-7.mol

Synonyms:methyl 4-[(aminoacetyl)amino]benzoate trifluoroacetic acid salt

Chemical Property of methyl 4-[(aminoacetyl)amino]benzoate trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

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Technology Process of methyl 4-[(aminoacetyl)amino]benzoate trifluoroacetic acid salt

There total 3 articles about methyl 4-[(aminoacetyl)amino]benzoate trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-{[(tertbutoxycarbonylamino)acetyl]amino}benzoate (250789-96-9) → methyl 4-[(aminoacetyl)amino]benzoate trifluoroacetic acid salt (1360821-85-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

Reference yield: 71.0%

methyl 4-{[(tertbutoxycarbonylamino)acetyl]amino}benzoate (250789-96-9) + trifluoroacetic acid (76-05-1) → methyl 4-[(aminoacetyl)amino]benzoate trifluoroacetic acid salt (1360821-85-7)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

DOI:10.1134/S1070428019060034

Reference yield:

4-methoxycarbonyl aniline (619-45-4) → methyl 4-[(aminoacetyl)amino]benzoate trifluoroacetic acid salt (1360821-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

4-methoxycarbonyl aniline

methyl 4-{[(tertbutoxycarbonylamino)acetyl]amino}benzoate

trifluoroacetic acid

Downstream raw materials:

(E)-methyl 4-(2-(3,3-dimethylbutylideneamino)acetamido)benzoate

methyl 4-((2S,3R,4S,5R)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate

methyl 4-((2R,3S,4R,5S)-6'-chloro-4-(3-chloro-2-fluorophenyl)-2-neopentyl-2'-oxo-1',2'-dihydrospiro[pyrrolidine-3,3'-pyrrolo[3,2-c]pyridine]-5-ylcarboxamido)benzoate