1-{(4S,5R)-5-[4-(6-chloromethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Base Information

Chemical Name:1-{(4S,5R)-5-[4-(6-chloromethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone
CAS No.:1454908-45-2
Molecular Formula:C₂₀H₂₀ClF₃N₂O₂
Molecular Weight:412.839
Hs Code.:

Synonyms:1-{(4S,5R)-5-[4-(6-chloromethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Suppliers and Price of 1-{(4S,5R)-5-[4-(6-chloromethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-{(4S,5R)-5-[4-(6-chloromethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-{(4S,5R)-5-[4-(6-chloromethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

There total 5 articles about 1-{(4S,5R)-5-[4-(6-chloromethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1454907-07-3
2,2-difluoro-1-{(4S,5R)-4-fluoromethyl-5-[4-(6-hydroxymethylpyridin-3-yl)phenyl]-2,2-dimethyloxazolidin-3-yl}ethanone

: 1454908-45-2
1-{(4S,5R)-5-[4-(6-chloromethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1454906-87-6
2,2-difluoro-1-((4S,5R)-4-(fluoromethyl)-2,2-dimethyl-5-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)oxazolidin-3-yl)ethanone

: 1454908-45-2
1-{(4S,5R)-5-[4-(6-chloromethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 6 h / 90 °C / Inert atmosphere

2: triethylamine; methanesulfonyl chloride / dichloromethane / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; methanesulfonyl chloride; triethylamine; In ethanol; dichloromethane; water; toluene;

Reference yield:

: 1431551-88-0
(4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine

: 1454908-45-2
1-{(4S,5R)-5-[4-(6-chloromethylpyridin-3-yl)phenyl]-4-fluoromethyl-2,2-dimethyloxazolidin-3-yl}-2,2-difluoroethanone

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

2: potassium acetate; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 22 h / 90 °C / Inert atmosphere

3: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 6 h / 90 °C / Inert atmosphere

4: triethylamine; methanesulfonyl chloride / dichloromethane / 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; methanesulfonyl chloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; water; toluene;