tert-butyl 4-(N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino)benzoate

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Chemical Name:tert-butyl 4-(N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino)benzoate
CAS No.:501169-65-9
Molecular Formula:C₂₃H₂₅N₃O₃
Molecular Weight:391.47
Hs Code.:

Synonyms:tert-butyl 4-(N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino)benzoate

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Chemical Property of tert-butyl 4-(N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino)benzoate

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Technology Process of tert-butyl 4-(N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino)benzoate

There total 5 articles about tert-butyl 4-(N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 501169-62-6
tert-butyl 4-[N-(5-acetamido-6-cyanoindan-1-yl)amino]benzoate

: 501169-65-9
tert-butyl 4-(N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino)benzoate

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; In ethanol; at 0 - 55 ℃; for 0.833333h;
DOI:10.1039/b301989f

Reference yield:

: 157701-33-2
5-acetylamino-6-bromoindane

: 501169-65-9
tert-butyl 4-(N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 43 percent / CrO₃ / acetic acid / 55 °C

2: p-TsOH*H₂O / 1,2-dimethoxy-ethane / 7 h / 110 °C

3: 0.520 g / sodium cyanoborohydride / methanol; acetic acid / 24 h / 20 °C

4: 70 percent / 1-methyl-pyrrolidin-2-one / 1.67 h / 140 °C

5: 83 percent / aq. H₂O₂; NaOH / ethanol / 0.83 h / 0 - 55 °C

With chromium(VI) oxide; sodium hydroxide; dihydrogen peroxide; sodium cyanoborohydride; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; ethanol; acetic acid; 4: Rosenmund-von Braun reaction;
DOI:10.1039/b301989f

Reference yield:

: 158205-18-6
5-Acetylamino-6-bromo-1-indanone

: 501169-65-9
tert-butyl 4-(N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH*H₂O / 1,2-dimethoxy-ethane / 7 h / 110 °C

2: 0.520 g / sodium cyanoborohydride / methanol; acetic acid / 24 h / 20 °C

3: 70 percent / 1-methyl-pyrrolidin-2-one / 1.67 h / 140 °C

4: 83 percent / aq. H₂O₂; NaOH / ethanol / 0.83 h / 0 - 55 °C

With sodium hydroxide; dihydrogen peroxide; sodium cyanoborohydride; toluene-4-sulfonic acid; In 1-methyl-pyrrolidin-2-one; methanol; 1,2-dimethoxyethane; ethanol; acetic acid; 3: Rosenmund-von Braun reaction;
DOI:10.1039/b301989f