157701-33-2

Basic information

• Product Name: N-(5-BROMO-2,3-DIHYDRO-1H-INDEN-6-YL)ACETAMIDE
• Synonyms: N-(5-BROMO-2,3-DIHYDRO-1H-INDEN-6-YL)ACETAMIDE;N-(6-BROMO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE;N-(6-BROMO-2,3-DIHYDRO-1H-INDEN-5-YL)ACETAMIDE(WXG01311)
• CAS NO: 157701-33-2
• Molecular Formula: C₁₁H₁₂BrNO
• Molecular Weight: 254.12
• Mol File: 157701-33-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 385.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.514±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.20±0.20(Predicted)
• CAS DataBase Reference: N-(5-BROMO-2,3-DIHYDRO-1H-INDEN-6-YL)ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-BROMO-2,3-DIHYDRO-1H-INDEN-6-YL)ACETAMIDE(157701-33-2)
• EPA Substance Registry System: N-(5-BROMO-2,3-DIHYDRO-1H-INDEN-6-YL)ACETAMIDE(157701-33-2)

Safety Data

• Hazardous Substances Data: 157701-33-2(Hazardous Substances Data)

Usage

Description

N-(5-Bromo-2,3-dihydro-1H-inden-6-yl)acetamide is a chemical compound that belongs to the class of acetamides. It is a white solid with a molecular formula of C11H11BrNO and a molecular weight of 252.11 g/mol. N-(5-BROMO-2,3-DIHYDRO-1H-INDEN-6-YL)ACETAMIDE is commonly used as a building block in the synthesis of more complex organic molecules and for studying the reactivity of different functional groups.

Uses

Used in Organic Synthesis:
N-(5-BROMO-2,3-DIHYDRO-1H-INDEN-6-YL)ACETAMIDE is used as a building block for the synthesis of more complex organic molecules. It is particularly useful in the creation of new compounds with potential applications in various fields.
Used in Pharmaceutical Research:
N-(5-BROMO-2,3-DIHYDRO-1H-INDEN-6-YL)ACETAMIDE is used as a research compound in the field of pharmaceuticals. It may have potential applications in the development of new drugs, although further research is needed to explore its therapeutic properties.
Used in Agrochemical Research:
N-(5-BROMO-2,3-DIHYDRO-1H-INDEN-6-YL)ACETAMIDE is also used in agrochemical research. It may have potential applications in the development of new pesticides or other agrochemical products, although further research is required to determine its effectiveness and safety.
Used in Laboratory Settings:
N-(5-BROMO-2,3-DIHYDRO-1H-INDEN-6-YL)ACETAMIDE is used in controlled laboratory settings for studying the reactivity of different functional groups. This helps researchers understand the chemical properties and potential applications of this compound.
It is important to handle N-(5-Bromo-2,3-dihydro-1H-inden-6-yl)acetamide with caution, as it may pose certain health hazards. Proper safety measures should be taken when working with this chemical compound in a laboratory setting.

Upstream product

• 59856-06-3 5-acetamidoindane 
• 7726-95-6 bromine 
• 64-19-7 acetic acid 
• 53474-09-2 6-bromo-2,3-dihydro-1H-inden-5-amine 
• 108-24-7 acetic anhydride 
• 24425-40-9 indan-5-amine 

Downstream Products

• 53474-09-2 6-bromo-2,3-dihydro-1H-inden-5-amine 
• 174487-71-9 4-{N-[(6R/6S)-2-Methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoic acid 
• 501169-57-9 tert-butyl 4-[N-(5-acetamido-6-bromoindan-1-yl)amino]benzoate 
• 501169-62-6 tert-butyl 4-[N-(5-acetamido-6-cyanoindan-1-yl)amino]benzoate 
• 501169-65-9 tert-butyl 4-(N-[(6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]amino)benzoate 
• 501169-69-3 tert-butyl 4-{N-[2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl]-N-(prop-2-ynyl)amino}benzoate 
• 1025942-01-1 C₁₇H₁₅F₂NO₅S₃ 
• 1028259-13-3 C₁₇H₁₆F₂N₂O₅S₂ 
• 1027952-32-4 C₁₈H₁₇NO₇S₃ 
• 1026588-02-2 C₁₇H₁₆FNO₅S₃ 
• 1026743-88-3 C₁₈H₁₉NO₆S₃ 
• 1027483-80-2 C₁₈H₁₉NO₆S₃ 
• 1027313-32-1 C₂₀H₂₃NO₅S₃ 

Relevant articles and documents

Synthesis of bromoaminoindane and bromoaminoindanone derivatives

The bromination reactions of 5-aminoindane, 5-acetamidoindane, and 5-acetamidoindan-1-one were investigated using NBS, molecular bromine and photobromination, and the optimum reaction conditions were presented. The reaction of 5-aminoindane with glacial acetic acid at reflux temperature resulted in the formation of 5-acetamidoindane in high yield. 5-Acetamidoindan-1-one was generated by the reaction of 5-acetamidoindane with CrO3 in acetic acid. Selective bromination at C-6 position of 5-acetamidoindane was achieved by treatment of title compound with bromine in acetic acid and thus afforded 5-acetamido-6-bromoindane. Further bromination reactions of bromoindanones were achieved in various reaction conditions.

Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity

IRAK4 kinase activity transduces signaling from multiple IL-1Rs and TLRs to regulate cytokines and chemokines implicated in inflammatory diseases. As such, there is high interest in identifying selective IRAK4 inhibitors for the treatment of these disorders. We previously reported the discovery of potent and selective dihydrobenzofuran inhibitors of IRAK4. Subsequent studies, however, showed inconsistent inhibition in disease-relevant pharmacodynamic models. Herein, we describe application of a human whole blood assay to the discovery of a series of benzolactam IRAK4 inhibitors. We identified potent molecule 19 that achieves robust in vivo inhibition of cytokines relevant to human disease.

PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Compounds of Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V), Formula (VI), Formula (VII), Formula (VIII), and methods of use as lnterleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.