METHYL4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)THIOPHENE-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)THIOPHENE-2-CARBOXYLATE
• CAS No.: 709648-80-6
• Molecular Formula: C12H17 B O4 S
• Molecular Weight: 268.142
• Hs Code.: 2934999090
• Mol file: 709648-80-6.mol

Synonyms:Methyl4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate

Chemical Property of METHYL4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)THIOPHENE-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.507
• Boiling Point: 374.586°C at 760 mmHg
• Flash Point: 180.344°C
• PSA: 73.00000
• Density: 1.162g/cm³
• LogP: 1.83390
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-thiophene-2-carboxylic acid methyl ester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)THIOPHENE-2-CARBOXYLATE

There total 2 articles about METHYL4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)THIOPHENE-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-bromothiophene-2-carboxylic acid methyl ester (62224-16-2) + bis(pinacol)diborane (73183-34-3) → methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-thiophene-2-carboxylate (709648-80-6)

Guidance literature:

With palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; anhydrous potassium acetate; In 1,4-dioxane; at 0 - 85 ℃; Inert atmosphere; Sealed tube;

Reference yield:

→ methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-thiophene-2-carboxylate (709648-80-6)

Guidance literature:

Reference yield: 90.0%

methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-thiophene-2-carboxylate (709648-80-6) + 3-bromo-6-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazolo[1,5-a]pyrimidine (945376-96-5) → methyl 4-(6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxylate

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 85 ℃; for 16h;

upstream raw materials:

4-bromothiophene-2-carboxylic acid methyl ester

bis(pinacol)diborane

Downstream raw materials:

methyl 4-(4-(4-aminophenoxy)pyridine-2-yl)thiophene-2-carboxylate

(5-(methoxycarbonyl)thiophen-3-yl)boronic acid

methyl 4-hydroxythiophene-2-carboxylate