Technology Process of C34H32N2O3
There total 4 articles about C34H32N2O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C27H26N2O3;
With
sodium hydride;
In
N,N-dimethyl-formamide; mineral oil;
at 0 - 20 ℃;
for 0.0833333h;
benzyl bromide;
In
N,N-dimethyl-formamide; mineral oil;
at 20 ℃;
for 1h;
DOI:10.1021/ol400845c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine / ethanol / 40 h / 20 °C / pH 7
2.1: toluene-4-sulfonic acid / methanol / 0.17 h / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 - 20 °C
3.2: 1 h / 20 °C
With
(S)-2-{bis[3,5-bis(trifluoromethyl)phenyl][(trimethylsilanyl)oxy]methyl}pyrrolidine; sodium hydride; toluene-4-sulfonic acid;
In
methanol; ethanol; N,N-dimethyl-formamide; mineral oil;
1.1: |Michael Addition;
DOI:10.1021/ol400845c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether / ethanol / 60 h / 20 °C / pH 7
2.1: toluene-4-sulfonic acid / methanol / 0.17 h / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 - 20 °C
3.2: 1 h / 20 °C
With
(R)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanoltrimethylsilyl ether; sodium hydride; toluene-4-sulfonic acid;
In
methanol; ethanol; N,N-dimethyl-formamide; mineral oil;
1.1: |Michael Addition;
DOI:10.1021/ol400845c