4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-morpholine

Base Information

Chemical Name:4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-morpholine
CAS No.:1092525-20-6
Molecular Formula:C₁₇H₂₄BF₂NO₃
Molecular Weight:339.19
Hs Code.:

Synonyms:4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-morpholine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-morpholine

Chemical Property:

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Technology Process of 4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-morpholine

There total 2 articles about 4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092563-36-4
4-(4-bromo-2,6-difluorobenzyl)morpholine

: 73183-34-3
bis(pinacol)diborane

: 1092525-20-6
4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-morpholine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In dichloromethane; N,N-dimethyl acetamide; at 80 ℃;
DOI:10.1016/j.bmcl.2010.01.069

Reference yield:

: 537013-51-7
4-bromo-2,6-difluorobenzaldehyde

: 1092525-20-6
4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-morpholine

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloroform / 1 h / 58 - 60 °C / Sealed tube

1.2: 60 h / 58 - 60 °C / Sealed tube

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; chloroform;

Reference yield:

: 1092525-20-6
4-[2,6-difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl]-morpholine

: 2-chloro-6-fluoro-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide

: 2-(3,5-difluoro-4-(morpholinomethyl)phenyl)-6-fluoro-N-(2-(pyrrolidin-1-yl)ethyl)quinoline-4-carboxamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; In water; N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Microwave irradiation;