4-{3-[(4-Chloro-benzenesulfonylamino)-phenyl-methyl]-phenyl}-butyric acid methyl ester

Base Information

Chemical Name:4-{3-[(4-Chloro-benzenesulfonylamino)-phenyl-methyl]-phenyl}-butyric acid methyl ester
CAS No.:177414-44-7
Molecular Formula:C₂₄H₂₄ClNO₄S
Molecular Weight:457.978
Hs Code.:

Synonyms:4-{3-[(4-Chloro-benzenesulfonylamino)-phenyl-methyl]-phenyl}-butyric acid methyl ester

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Chemical Property of 4-{3-[(4-Chloro-benzenesulfonylamino)-phenyl-methyl]-phenyl}-butyric acid methyl ester

Chemical Property:

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Technology Process of 4-{3-[(4-Chloro-benzenesulfonylamino)-phenyl-methyl]-phenyl}-butyric acid methyl ester

There total 5 articles about 4-{3-[(4-Chloro-benzenesulfonylamino)-phenyl-methyl]-phenyl}-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 177414-40-3
4-[3-(Amino-phenyl-methyl)-phenyl]-butyric acid methyl ester

: 177414-44-7
4-{3-[(4-Chloro-benzenesulfonylamino)-phenyl-methyl]-phenyl}-butyric acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1248/cpb.44.765

Reference yield:

: 4-(3-Benzoyl-phenyl)-butyric acid methyl ester

: 177414-44-7
4-{3-[(4-Chloro-benzenesulfonylamino)-phenyl-methyl]-phenyl}-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: NaBH₄ / methanol / Ambient temperature

2: SOCl₂ / benzene / Heating

3: NaN₃ / dimethylformamide / 50 - 60 °C

4: 87 percent / H₂ / PtO₂ / methanol / 760 Torr / Ambient temperature

5: 86 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With sodium tetrahydroborate; thionyl chloride; sodium azide; hydrogen; triethylamine; platinum(IV) oxide; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.44.765

Reference yield:

: 177414-29-8
4-[3-(Hydroxy-phenyl-methyl)-phenyl]-butyric acid methyl ester

: 177414-44-7
4-{3-[(4-Chloro-benzenesulfonylamino)-phenyl-methyl]-phenyl}-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / benzene / Heating

2: NaN₃ / dimethylformamide / 50 - 60 °C

3: 87 percent / H₂ / PtO₂ / methanol / 760 Torr / Ambient temperature

4: 86 percent / Et₃N / CH₂Cl₂ / Ambient temperature

With thionyl chloride; sodium azide; hydrogen; triethylamine; platinum(IV) oxide; In methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.44.765