(2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]phenyl]but-2-enoyl-Haic-(R)-4-aminopentamide

Base Information

Chemical Name:(2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]phenyl]but-2-enoyl-Haic-(R)-4-aminopentamide
CAS No.:1247847-27-3
Molecular Formula:C₄₁H₅₃F₂N₄O₁₁P
Molecular Weight:846.863
Hs Code.:

Synonyms:(2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]phenyl]but-2-enoyl-Haic-(R)-4-aminopentamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]phenyl]but-2-enoyl-Haic-(R)-4-aminopentamide

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Technology Process of (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]phenyl]but-2-enoyl-Haic-(R)-4-aminopentamide

There total 18 articles about (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]phenyl]but-2-enoyl-Haic-(R)-4-aminopentamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1247847-56-8
pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate

: 1304101-69-6
TFA*H-Haic-NHCH(CH₃)CH₂CH₂CONH₂

: 1247847-27-3
(2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]phenyl]but-2-enoyl-Haic-(R)-4-aminopentamide

Guidance literature:: With 4-methyl-morpholine; dmap; In 1-methyl-pyrrolidin-2-one; acetonitrile; for 1h; Inert atmosphere;

Reference yield: 33.0%

: 1247847-56-8
pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate

: 1304101-69-6
TFA*H-Haic-NHCH(CH₃)CH₂CH₂CONH₂

: 1247847-27-3
(2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]phenyl]but-2-enoyl-Haic-(R)-4-aminopentamide

: 1304101-64-1
C₃₅H₄₃F₂N₄O₉P

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1021/jm2000882