pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate

Base Information

Chemical Name:pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate
CAS No.:1247847-56-8
Molecular Formula:C₂₉H₃₀Cl₅F₂O₉P
Molecular Weight:768.787
Hs Code.:

Synonyms:pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate

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Chemical Property of pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate

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Technology Process of pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate

There total 7 articles about pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1247847-55-7
pentachlorophenyl (2E)-3-[4-(Phosphoryldifluoromethyl)phenyl]but-2-enoate

: 53064-79-2
iodomethyl pivaloate

: 1247847-56-8
pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate

Guidance literature:: pentachlorophenyl (2E)-3-[4-(Phosphoryldifluoromethyl)phenyl]but-2-enoate; With sodium hydroxide; In water; pH=~ 9;

With silver nitrate; In water; at 4 ℃; for 2h;

iodomethyl pivaloate; In toluene; at 20 ℃; for 48h;

Reference yield:

: 1247847-52-4
tert-butyl (2E)-3-[4-[(diethoxyphosphinyl)difluoromethyl]phenyl]but-2-enoate

: 1247847-56-8
pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.1: dmap; dicyclohexyl-carbodiimide / ethyl acetate / 24 h / 20 °C

3.1: trimethylsilyl iodide; 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

4.1: silver nitrate; sodium hydroxide / water / 2 h / 4 °C / pH 9

4.2: 48 h / 20 °C

With dmap; trimethylsilyl iodide; 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide; silver nitrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide; In dichloromethane; water; ethyl acetate;
DOI:10.1021/jm2000882

Reference yield:

: 1247847-54-6
(E)-3-(4-((diethoxyphosphoryl)-difluoromethyl)phenyl)but-2-enoic acid

: 1247847-56-8
pentachlorophenyl (2E)-3-[4-[[bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]difluoromethyl]-phenyl]but-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / ethyl acetate / 24 h / 20 °C

2.1: trimethylsilyl iodide; 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3.1: silver nitrate; sodium hydroxide / water / 2 h / 4 °C / pH 9

3.2: 48 h / 20 °C

With dmap; trimethylsilyl iodide; 2,2,2-trifluoro-N,N-bis(trimethylsilyl)-acetamide; silver nitrate; dicyclohexyl-carbodiimide; sodium hydroxide; In dichloromethane; water; ethyl acetate;
DOI:10.1021/jm2000882