N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Base Information

Chemical Name:N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide
CAS No.:1333127-27-7
Molecular Formula:C₂₃H₂₂Cl₂FN₅O₃
Molecular Weight:506.364
Hs Code.:

Synonyms:N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

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Chemical Property of N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Chemical Property:

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Technology Process of N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

There total 6 articles about N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333127-26-6
N-(5-chloropyridine-2-yl)-2-[4-(trifluoroacetyl(methyl)amino)-2-(3-(trifluoroacetylamino)propoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

: 1333127-27-7
N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Guidance literature:: With water; sodium hydroxide; In ethanol; for 1h;

Reference yield:

: 1333127-45-9
4-methylamino-6-fluorosalicylic acid

: 1333127-27-7
N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / 1,4-dioxane; water / 24 h

2: potassium carbonate / 1 h / 110 °C

3: hydrogenchloride; water / ethanol / 2 h

4: 1 h

5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

6: sodium hydroxide; water / ethanol / 1 h

With hydrogenchloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; water;

Reference yield:

: 1333127-20-0
4-(tertbutoxycarbonyl(methyl)amino)-6-fluorosalicylic acid

: 1333127-27-7
N-(5-chloropyridine-2-yl)-2-[4-methylamino-2-(3-aminopropoxy)-6-fluorophenylcarbonylamino]-5-chlorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / 1 h / 110 °C

2: hydrogenchloride; water / ethanol / 2 h

3: 1 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran / 48 h

5: sodium hydroxide; water / ethanol / 1 h

With hydrogenchloride; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol;