2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester

Base Information

Chemical Name:2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester
CAS No.:915975-01-8
Molecular Formula:C₄₁H₅₈N₂O₅Si₂
Molecular Weight:715.093
Hs Code.:

2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester

Synonyms:2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester

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Chemical Property of 2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester

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Technology Process of 2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester

There total 6 articles about 2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1026590-33-9
2-methyl-acrylic acid 2-(1-chloro-3-oxo-1-phenyl-1,3-dihydro-isoindol-2-yl)-ethyl ester

: 191418-28-7
2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamine

: 915975-01-8
2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1021/jm0601194

Reference yield:

: 878022-23-2
2-methylacrylic acid 2-(1-hydroxy-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl)ethyl ester

: 915975-01-8
2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂; DMF / tetrahydrofuran / 16 h

2: 0.19 g / Et₃N / dimethylformamide / 20 h / 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0601194

Reference yield:

: 85-52-9
2-Benzoylbenzoic acid

: 915975-01-8
2-methacrylic acid 2-{1-[2-(tert-butyldimethylsilanyloxy)-1-(t-butyldimethylsilanyloxymethyl)-2-phenylethylamino]-3-oxo-1-phenyl-1,3-dihydroisoindol-2-yl}ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride; DMF / tetrahydrofuran / 16 h / 20 °C

2: 1.04 g / Et₃N / tetrahydrofuran / 16 h / 20 °C

3: SOCl₂; DMF / tetrahydrofuran / 16 h

4: 0.19 g / Et₃N / dimethylformamide / 20 h / 20 °C

With thionyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0601194