benzyl 4-(benzyloxy)-3-chlorobenzoate

Base Information

• Chemical Name: benzyl 4-(benzyloxy)-3-chlorobenzoate
• CAS No.: 159465-83-5
• Molecular Formula: C₂₁H₁₇ClO₃
• Molecular Weight: 352.817
• Mol file: 159465-83-5.mol

Synonyms:benzyl 4-(benzyloxy)-3-chlorobenzoate

Chemical Property of benzyl 4-(benzyloxy)-3-chlorobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-(benzyloxy)-3-chlorobenzoate

There total 1 articles about benzyl 4-(benzyloxy)-3-chlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-hydroxybenzoic acid (3964-58-7) + benzyl bromide (100-39-0) → benzyl 4-(benzyloxy)-3-chlorobenzoate (159465-83-5)

Guidance literature:

In N,N-dimethyl-formamide;

DOI:10.1016/0040-4039(96)01829-1

Reference yield:

benzyl 4-(benzyloxy)-3-chlorobenzoate (159465-83-5) → 4-(benzyloxy)-3-chlorobenzoic acid (106931-79-7)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

benzyl 4-(benzyloxy)-3-chlorobenzoate (159465-83-5) → (2R,3R)-3-(3-Chloro-4-hydroxy-phenyl)-2-hydrazino-3-hydroxy-propionic acid methyl ester

Guidance literature:

Multi-step reaction with 7 steps

1: 2N NaOH / methanol

2: SOCl₂

3: MgCl₂, Et₃N / acetonitrile

4: 100 percent / hydrogen, RuBr₂<(R)-Binap> / CH₂Cl₂ / 27 °C / 4500.4 Torr

5: 1.) MeZnBr; 2. ) LDA; 3.) NH₄Cl / 1.) 0 deg C; 2.) -78 deg C; 3.) H₂O, -78 deg C

6: hydrogen / Pd/C / methanol

7: CF₃CO₂H / CH₂Cl₂

With sodium hydroxide; thionyl chloride; [(R)-BINAP]RuBr₂; hydrogen; ammonium chloride; triethylamine; trifluoroacetic acid; magnesium chloride; lithium diisopropyl amide; zinc methyl bromide; palladium on activated charcoal; In methanol; dichloromethane; acetonitrile;

DOI:10.1016/0040-4039(96)01829-1

upstream raw materials:

3-chloro-4-hydroxybenzoic acid

benzyl bromide

Downstream raw materials:

4-benzyloxy-3-chloro-benzoic acid methyl ester

4-benzyloxy-3-chlorobenzoic acid chloride

3-(4-Benzyloxy-3-chloro-phenyl)-3-oxo-propionic acid methyl ester

(S)-3-(4-Benzyloxy-3-chloro-phenyl)-3-hydroxy-propionic acid methyl ester