(4-amino-1H-pyrrolo[3,2-c]pyridin-1-yl)(2-chloro-6-fluorophenyl)methanone

Base Information

Chemical Name:(4-amino-1H-pyrrolo[3,2-c]pyridin-1-yl)(2-chloro-6-fluorophenyl)methanone
CAS No.:1415124-06-9
Molecular Formula:C₁₄H₉ClFN₃O
Molecular Weight:289.696
Hs Code.:

Synonyms:(4-amino-1H-pyrrolo[3,2-c]pyridin-1-yl)(2-chloro-6-fluorophenyl)methanone

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Chemical Property of (4-amino-1H-pyrrolo[3,2-c]pyridin-1-yl)(2-chloro-6-fluorophenyl)methanone

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Technology Process of (4-amino-1H-pyrrolo[3,2-c]pyridin-1-yl)(2-chloro-6-fluorophenyl)methanone

There total 8 articles about (4-amino-1H-pyrrolo[3,2-c]pyridin-1-yl)(2-chloro-6-fluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.45%

: 1415125-07-3
(2-chloro-6-fluorophenyl){4-[(2,4,4-trimethylpentan-2-yl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}methanone

: 1415124-06-9
(4-amino-1H-pyrrolo[3,2-c]pyridin-1-yl)(2-chloro-6-fluorophenyl)methanone

Guidance literature:: (2-chloro-6-fluorophenyl){4-[(2,4,4-trimethylpentan-2-yl)amino]-1H-pyrrolo[3,2-c]pyridin-1-yl}methanone; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With ammonia; In water;

Reference yield:

: 271-34-1
5-azaindole

: 1415124-06-9
(4-amino-1H-pyrrolo[3,2-c]pyridin-1-yl)(2-chloro-6-fluorophenyl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.75 h / 0 - 20 °C

1.2: 20 h / 20 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

3.1: p-toluenesulfonyl chloride / chloroform / 0.17 h / 0 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With oxalyl dichloride; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; N,N-dimethyl-formamide; In dichloromethane; chloroform;

Reference yield:

: 108-99-6
3-Methylpyridine

: 1415124-06-9
(4-amino-1H-pyrrolo[3,2-c]pyridin-1-yl)(2-chloro-6-fluorophenyl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1.1: dihydrogen peroxide / acetic acid / 70 °C / Cooling with ice

2.1: nitric acid / sulfuric acid / 2 h / 0 - 100 °C

3.1: dimethyl amine / N,N-dimethyl-formamide / 15 h / 90 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1.75 h / 0 - 20 °C

5.2: 20 h / 20 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

7.1: p-toluenesulfonyl chloride / chloroform / 0.17 h / 0 °C

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With oxalyl dichloride; hydrogen; dihydrogen peroxide; nitric acid; dimethyl amine; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; sulfuric acid; palladium 10% on activated carbon; N,N-dimethyl-formamide; In methanol; dichloromethane; chloroform; acetic acid; N,N-dimethyl-formamide;