Technology Process of 4-(aminomethyl)-2-bromobenzonitrile hydrochloride
There total 6 articles about 4-(aminomethyl)-2-bromobenzonitrile hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-bromo-4-((1,3-dioxoisoindolin-2-yl)methyl)benzonitrile;
With
hydrazine hydrate;
In
ethanol;
for 3h;
Reflux;
With
hydrogenchloride;
In
methanol; water;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: thionyl chloride / N,N-dimethyl-formamide / toluene / 3 h / 50 °C
2: ammonia / water; toluene
3: phosphorus pentoxide / chloroform / 12 h / Reflux
4: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 4 h / Reflux
5: N,N-dimethyl-formamide / 4 h / Reflux
6: hydrazine hydrate / ethanol / 3 h / Reflux
With
N-Bromosuccinimide; thionyl chloride; phosphorus pentoxide; ammonia; hydrazine hydrate; dibenzoyl peroxide;
N,N-dimethyl-formamide;
In
tetrachloromethane; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N,N-dimethyl-formamide / 4 h / Reflux
2: hydrazine hydrate / ethanol / 3 h / Reflux
With
hydrazine hydrate;
In
ethanol; N,N-dimethyl-formamide;
