tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate

Base Information

Chemical Name:tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate
CAS No.:1615249-84-7
Molecular Formula:C₂₃H₃₂ClN₃O₄
Molecular Weight:449.978
Hs Code.:

Synonyms:tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate

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Chemical Property of tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate

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Technology Process of tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate

There total 4 articles about tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1016167-99-9
(S)-1-piperidin-3-ylmethylcarbamic acid tert-butyl ester

: 116404-24-1,59749-22-3
(S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carboxylic acid

: 1615249-84-7
tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate

Guidance literature:: (S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carboxylic acid; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 0.25h;

(S)-1-piperidin-3-ylmethylcarbamic acid tert-butyl ester; In dichloromethane; at 0 ℃; for 3h;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 622-95-7
4-chlorobenzyl bromide

: 1615249-84-7
tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

3.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.25 h / 0 °C

3.2: 3 h / 0 °C

With water; sodium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 59749-18-7
(S)-1-(4-Chloro-benzyl)-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

: 1615249-84-7
tert-butyl ((R)-1-((S)-1-(4-chlorobenzyl)-5-oxopyrrolidine-2-carbonyl) piperidin-3-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 0.25 h / 0 °C

2.2: 3 h / 0 °C

With water; sodium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017