(2S,3R,3aS,12bR)-1,2,3,3a,4,5,7,8-octahydro-10-benzyloxy-2-methyl-3-nitromethyl-5-oxo-cyclopenta[2,3]pyrrolo[2,1-a]isoquinoline

Base Information

Chemical Name:(2S,3R,3aS,12bR)-1,2,3,3a,4,5,7,8-octahydro-10-benzyloxy-2-methyl-3-nitromethyl-5-oxo-cyclopenta[2,3]pyrrolo[2,1-a]isoquinoline
CAS No.:1415684-09-1
Molecular Formula:C₂₄H₂₆N₂O₄
Molecular Weight:406.481
Hs Code.:

Synonyms:(2S,3R,3aS,12bR)-1,2,3,3a,4,5,7,8-octahydro-10-benzyloxy-2-methyl-3-nitromethyl-5-oxo-cyclopenta[2,3]pyrrolo[2,1-a]isoquinoline

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Chemical Property of (2S,3R,3aS,12bR)-1,2,3,3a,4,5,7,8-octahydro-10-benzyloxy-2-methyl-3-nitromethyl-5-oxo-cyclopenta[2,3]pyrrolo[2,1-a]isoquinoline

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Technology Process of (2S,3R,3aS,12bR)-1,2,3,3a,4,5,7,8-octahydro-10-benzyloxy-2-methyl-3-nitromethyl-5-oxo-cyclopenta[2,3]pyrrolo[2,1-a]isoquinoline

There total 7 articles about (2S,3R,3aS,12bR)-1,2,3,3a,4,5,7,8-octahydro-10-benzyloxy-2-methyl-3-nitromethyl-5-oxo-cyclopenta[2,3]pyrrolo[2,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₈N₂O₅

: 1415684-09-1
(2S,3R,3aS,12bR)-1,2,3,3a,4,5,7,8-octahydro-10-benzyloxy-2-methyl-3-nitromethyl-5-oxo-cyclopenta[2,3]pyrrolo[2,1-a]isoquinoline

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2012.10.038

Reference yield:

: C₂₄H₂₈N₂O₅

: 1415684-09-1
(2S,3R,3aS,12bR)-1,2,3,3a,4,5,7,8-octahydro-10-benzyloxy-2-methyl-3-nitromethyl-5-oxo-cyclopenta[2,3]pyrrolo[2,1-a]isoquinoline

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 123000-45-3
[1S-(1β,2α,3β)]-(+)-3-methyl-2-(nitromethyl)-5-oxocyclopentan-1-ylacetic acid

: 1415684-09-1
(2S,3R,3aS,12bR)-1,2,3,3a,4,5,7,8-octahydro-10-benzyloxy-2-methyl-3-nitromethyl-5-oxo-cyclopenta[2,3]pyrrolo[2,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tet.2012.10.038