1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S,4R)-(9CI)

Base Information

Chemical Name:1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S,4R)-(9CI)
CAS No.:708274-46-8
Molecular Formula:C10H20 N2 O2
Molecular Weight:200.281
Hs Code.:
Mol file:708274-46-8.mol

Synonyms:1,1-Dimethylethyl(2S,4R)-4-amino-2-methyl-1-pyrrolidinecarboxylate; tert-Butyl(2S,4R)-4-Amino-2-methylpyrrolidine-1-carboxylate

Suppliers and Price of 1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S,4R)-(9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
tert-butyl(2S,4R)-4-amino-2-methylpyrrolidine-1-carboxylate
100mg
$ 75.00

Total 7 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S,4R)-(9CI)

Chemical Property:

PSA：55.56000
LogP:1.98120

Purity/Quality:

99%, ^*data from raw suppliers

tert-butyl(2S,4R)-4-amino-2-methylpyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S,4R)-(9CI)

There total 10 articles about 1-Pyrrolidinecarboxylicacid,4-amino-2-methyl-,1,1-dimethylethylester,(2S,4R)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 708274-45-7
1,2-dimethylethyl-(2S,4R)-4-azido-2-methyl-1-pyrrolidinecarboxylate

: 708274-46-8,348165-63-9
1,1-dimethylethyl (2S,4R)-4-amino-2-methyl-1-pyrrolidinecarboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol;

Reference yield:

: 791602-89-6
4-(tert-butyldimethylsilanyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 708274-46-8,348165-63-9
1,1-dimethylethyl (2S,4R)-4-amino-2-methyl-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: lithium borohydride

2: triethylamine

3: lithium triethylborohydride

4: tetrabutyl ammonium fluoride / tetrahydrofuran

5: triethylamine

6: t-butyl ammonium azide / acetonitrile

7: 10% palladium on activated charcoal; hydrogen / methanol

With lithium borohydride; 10% palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; lithium triethylborohydride; triethylamine; t-butyl ammonium azide; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/ml100212k

Reference yield:

: 1123305-80-5
1,1-dimethylethyl (2S,4S)-4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-methyl-1-pyrrolidinecarboxylate

: 708274-46-8,348165-63-9
1,1-dimethylethyl (2S,4R)-4-amino-2-methyl-1-pyrrolidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran

2: triethylamine

3: t-butyl ammonium azide / acetonitrile

4: 10% palladium on activated charcoal; hydrogen / methanol

With 10% palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; triethylamine; t-butyl ammonium azide; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1021/ml100212k