6-fluoropyridine-3-sulfonyl chloride

Base Information

• Chemical Name: 6-fluoropyridine-3-sulfonyl chloride
• CAS No.: 1025509-80-1
• Molecular Formula: C₅H₃ClFNO₂S
• Molecular Weight: 195.602
• Mol file: 1025509-80-1.mol

Synonyms:6-fluoropyridine-3-sulfonyl chloride

Chemical Property of 6-fluoropyridine-3-sulfonyl chloride

Chemical Property:

Purity/Quality:

98%+ ^*data from raw suppliers

6-Fluoropyridine-3-sulfonylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-fluoropyridine-3-sulfonyl chloride

There total 2 articles about 6-fluoropyridine-3-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-(benzylsulfanyl)-2-fluoropyridine → 6-fluoropyridine-3-sulfonyl chloride (1025509-80-1)

Guidance literature:

With trichloroisocyanuric acid; acetic acid; In water; acetonitrile; at 20 ℃; for 1.5h;

Reference yield:

5-bromo-2-fluoropyridine (766-11-0) → 6-fluoropyridine-3-sulfonyl chloride (1025509-80-1)

Guidance literature:

5-bromo-2-fluoropyridine; With n-butyllithium; dibutylmagnesium; In tetrahydrofuran; at -10 - 10 ℃; Inert atmosphere;

With sulfuryl dichloride; In tetrahydrofuran; toluene; at -10 ℃;

DOI:10.1055/s-0030-1259953

Reference yield:

6-fluoropyridine-3-sulfonyl chloride (1025509-80-1) + benzyl (R)-2-(benzyloxy)-4-(N-((5-cyclohexylpyrazin-2-yl)methyl)azetidine-2-carboxamido)benzoate → benzyl (R)-2-(benzyloxy)-4-(N-((5-cyclohexylpyrazin-2-yl)methyl)-1-((6-fluoropyridin-3-yl)sulfonyl)azetidine-2-carboxamido)benzoate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

upstream raw materials:

5-bromo-2-fluoropyridine

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