N-methyl-N-[(1R)-1-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide

Base Information

Chemical Name:N-methyl-N-[(1R)-1-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide
CAS No.:922515-98-8
Molecular Formula:C₁₉H₂₅N₃OS
Molecular Weight:343.493
Hs Code.:

Synonyms:N-methyl-N-[(1R)-1-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide

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Chemical Property of N-methyl-N-[(1R)-1-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide

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Technology Process of N-methyl-N-[(1R)-1-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide

There total 3 articles about N-methyl-N-[(1R)-1-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 922515-97-7
1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate

: 922515-98-8
N-methyl-N-[(1R)-1-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide

Guidance literature:: 1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate; With hydrogenchloride; In 1,4-dioxane; diethyl ether; at 20 ℃; for 5h;

With sodium hydroxide; In water;

Reference yield:

: 214834-18-1
tert-butyl 4-carbamothioylpiperidine-1-carboxylate

: 922515-98-8
N-methyl-N-[(1R)-1-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 0 - 20 °C

2: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 20 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 96 h / 20 °C

4: hydrogenchloride / 1,4-dioxane; diethyl ether / 4 h / 20 °C

With hydrogenchloride; sodium hydroxide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; acetonitrile;

Reference yield:

: 365413-31-6
ethyl 2-(1-(tert-butoxy carbonyl )piperidin-4-yl)thiazole-4-carboxylate

: 922515-98-8
N-methyl-N-[(1R)-1-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 20 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 96 h / 20 °C

3: hydrogenchloride / 1,4-dioxane; diethyl ether / 4 h / 20 °C

With hydrogenchloride; sodium hydroxide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; acetonitrile;