1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate
CAS No.:922515-97-7
Molecular Formula:C₂₄H₃₃N₃O₃S
Molecular Weight:443.61
Hs Code.:

Synonyms:1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate

Chemical Property:

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Technology Process of 1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate

There total 3 articles about 1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 365413-00-9
4-(4-carboxy-thiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 128257-18-1
(R)-N-Methyl-1-phenylpropylamine

: 922515-97-7
1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In acetonitrile; at 20 ℃; for 96h;

Reference yield:

: 214834-18-1
tert-butyl 4-carbamothioylpiperidine-1-carboxylate

: 922515-97-7
1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 0 - 20 °C

2: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 20 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 96 h / 20 °C

With sodium hydroxide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; ethanol; acetonitrile;

Reference yield:

: 365413-31-6
ethyl 2-(1-(tert-butoxy carbonyl )piperidin-4-yl)thiazole-4-carboxylate

: 922515-97-7
1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 20 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / acetonitrile / 96 h / 20 °C

With sodium hydroxide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; methanol; acetonitrile;