N-tert-butyl-2-(1,4-dioxo-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-(3,4,5-trimethoxyphenyl)acetamide

Base Information

• Chemical Name: N-tert-butyl-2-(1,4-dioxo-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-(3,4,5-trimethoxyphenyl)acetamide
• CAS No.: 1404118-42-8
• Molecular Formula: C₂₂H₂₇N₃O₆
• Molecular Weight: 429.473

Synonyms:N-tert-butyl-2-(1,4-dioxo-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-(3,4,5-trimethoxyphenyl)acetamide

Chemical Property of N-tert-butyl-2-(1,4-dioxo-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-(3,4,5-trimethoxyphenyl)acetamide

Chemical Property:

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Technology Process of N-tert-butyl-2-(1,4-dioxo-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-(3,4,5-trimethoxyphenyl)acetamide

There total 2 articles about N-tert-butyl-2-(1,4-dioxo-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-(3,4,5-trimethoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

tert-butylisonitrile (119072-55-8,7188-38-7) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) + pyrrole-2-carboxyl acid (634-97-9) → N-tert-butyl-2-(1,4-dioxo-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-(3,4,5-trimethoxyphenyl)acetamide (1404118-42-8)

Guidance literature:

glycine ethyl ester hydrochloride; With triethylamine; In methanol; at 20 ℃; for 0.166667h;

tert-butylisonitrile; 3,4,5-trimethoxy-benzaldehyde; pyrrole-2-carboxyl acid; In methanol; at 20 ℃; for 2.16667h;

DOI:10.1021/jo3018704

Reference yield:

tert-butylisonitrile (119072-55-8,7188-38-7) + 3,4,5-trimethoxy-benzaldehyde (86-81-7) + methoxycarbonylmethylamine (616-34-2) + pyrrole-2-carboxyl acid (634-97-9) → N-tert-butyl-2-(1,4-dioxo-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-(3,4,5-trimethoxyphenyl)acetamide (1404118-42-8)

Guidance literature:

at 20 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2016.01.028

Reference yield: 80.0%

N-tert-butyl-2-(1,4-dioxo-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-2-(3,4,5-trimethoxyphenyl)acetamide (1404118-42-8) + 4-methoxy-benzylamine (2393-23-9) → N-(2-(tert-butylamino)-2-oxo-1-(3,4,5-trimethoxyphenyl)ethyl)-N-(2-(4-methoxybenzyl amino)-2-oxoethyl)-1H-pyrrole-2-carboxamide (1404118-52-0)

Guidance literature:

In ethanol; regioselective reaction; Reflux;

DOI:10.1021/jo3018704

upstream raw materials:

tert-butylisonitrile

glycine ethyl ester hydrochloride

3,4,5-trimethoxy-benzaldehyde

pyrrole-2-carboxyl acid

Downstream raw materials:

N-(2-(tert-butylamino)-2-oxo-1-(3,4,5-trimethoxyphenyl)ethyl)-N-(2-(4-methoxybenzyl amino)-2-oxoethyl)-1H-pyrrole-2-carboxamide

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