2-METHYL-2-[4-{[(4-METHYL-2-[4-TRIFLUOROMETHYL PHENYL]-THIAZOL-5-YLMETHYL)-N-(2, 2, 2-TRIFLUOROETHYL)-AMINO]METHYL}PHENOXY]PROPIONIC ACID

Base Information

Chemical Name:2-METHYL-2-[4-{[(4-METHYL-2-[4-TRIFLUOROMETHYL PHENYL]-THIAZOL-5-YLMETHYL)-N-(2, 2, 2-TRIFLUOROETHYL)-AMINO]METHYL}PHENOXY]PROPIONIC ACID
CAS No.:639783-87-2
Molecular Formula:C₂₅H₂₄F₆N₂O₃S
Molecular Weight:546.534
Hs Code.:

Synonyms:2-METHYL-2-[4-{[(4-METHYL-2-[4-TRIFLUOROMETHYL PHENYL]-THIAZOL-5-YLMETHYL)-N-(2, 2, 2-TRIFLUOROETHYL)-AMINO]METHYL}PHENOXY]PROPIONIC ACID

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Chemical Property of 2-METHYL-2-[4-{[(4-METHYL-2-[4-TRIFLUOROMETHYL PHENYL]-THIAZOL-5-YLMETHYL)-N-(2, 2, 2-TRIFLUOROETHYL)-AMINO]METHYL}PHENOXY]PROPIONIC ACID

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Technology Process of 2-METHYL-2-[4-{[(4-METHYL-2-[4-TRIFLUOROMETHYL PHENYL]-THIAZOL-5-YLMETHYL)-N-(2, 2, 2-TRIFLUOROETHYL)-AMINO]METHYL}PHENOXY]PROPIONIC ACID

There total 3 articles about 2-METHYL-2-[4-{[(4-METHYL-2-[4-TRIFLUOROMETHYL PHENYL]-THIAZOL-5-YLMETHYL)-N-(2, 2, 2-TRIFLUOROETHYL)-AMINO]METHYL}PHENOXY]PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.66%

: 639783-70-3
Example 42

: 639783-87-2
2-METHYL-2-[4-{[(4-METHYL-2-[4-TRIFLUOROMETHYL PHENYL]-THIAZOL-5-YLMETHYL)-N-(2, 2, 2-TRIFLUOROETHYL)-AMINO]METHYL}PHENOXY]PROPIONIC ACID

Guidance literature:: Example 42; With sodium hydroxide; at 60 ℃; for 12h;

With hydrogenchloride;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 639783-87-2
2-METHYL-2-[4-{[(4-METHYL-2-[4-TRIFLUOROMETHYL PHENYL]-THIAZOL-5-YLMETHYL)-N-(2, 2, 2-TRIFLUOROETHYL)-AMINO]METHYL}PHENOXY]PROPIONIC ACID

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 0.5 h / 25 °C

1.2: 3 h

1.3: 16 h

2.1: sodium triacetoxy borohydride; trifluoroethylamine / dichloromethane / 12 h / 25 °C

3.1: potassium carbonate; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole / 1 h

4.1: sodium hydroxide / 12 h / 60 °C

With sodium triacetoxy borohydride; trifluoroethylamine; sodium hydroxide; potassium carbonate; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole; In dichloromethane; acetone;

Reference yield:

: 639784-48-8
ETHYL-2-METHYL-2-[(4-(N-(2,2,2-trifluoroethyl)aminomethyl)phenoxy)]-propanoate

: 639783-87-2
2-METHYL-2-[4-{[(4-METHYL-2-[4-TRIFLUOROMETHYL PHENYL]-THIAZOL-5-YLMETHYL)-N-(2, 2, 2-TRIFLUOROETHYL)-AMINO]METHYL}PHENOXY]PROPIONIC ACID

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole / 1 h

2: sodium hydroxide / 12 h / 60 °C

With sodium hydroxide; potassium carbonate; 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole;