2-chloro-N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine

Base Information

Chemical Name:2-chloro-N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine
CAS No.:1019855-84-5
Molecular Formula:C₁₄H₁₄ClFN₄O₂S
Molecular Weight:356.808
Hs Code.:

2-chloro-N<sub>4</sub>-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine

Synonyms:2-chloro-N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine

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Chemical Property of 2-chloro-N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine

Chemical Property:

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Technology Process of 2-chloro-N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine

There total 2 articles about 2-chloro-N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1019855-83-4
N-cyclopropylsulfonyl-4-aminobenzylamine

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

: 1019855-84-5
2-chloro-N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine

Guidance literature:: In methanol; water; at 20 ℃;

Reference yield:

: 18600-42-5
4-nitrobenzylamine hydrochloride

: 1019855-84-5
2-chloro-N₄-(4-cyclopropylsulfonylaminomethyl)phenyl-5-fluoro-4-pyrimidineamine

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 2068.65 Torr

3: methanol; water / 20 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; water;