4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1-tert-butoxycarbonylpiperidine

Base Information

Chemical Name:4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1-tert-butoxycarbonylpiperidine
CAS No.:951745-06-5
Molecular Formula:C₂₇H₃₂N₂O₄S
Molecular Weight:480.628
Hs Code.:

Synonyms:4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1-tert-butoxycarbonylpiperidine

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Chemical Property of 4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1-tert-butoxycarbonylpiperidine

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Technology Process of 4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1-tert-butoxycarbonylpiperidine

There total 2 articles about 4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1-tert-butoxycarbonylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 214834-18-1
tert-butyl 4-carbamothioylpiperidine-1-carboxylate

: 27895-95-0
2-bromo-1,2-bis(4-methoxyphenyl)ethanone

: 951745-06-5
4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1-tert-butoxycarbonylpiperidine

Guidance literature:: In methanol; at 20 ℃; for 2 - 4h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 120-44-5
1,4-di(4-methoxyphenyl)ethanone

: 951745-06-5
4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1-tert-butoxycarbonylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridinium hydrobromide perbromide / dichloromethane / 1 h / 20 °C

2: methanol / 2 - 4 h / 20 °C / Heating / reflux

With pyridinium hydrobromide perbromide; In methanol; dichloromethane;

Reference yield: 80.0%

: 951745-06-5
4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1-tert-butoxycarbonylpiperidine

: 951745-07-6
1-tert-butoxycarbonyl-4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-4-hydroxypiperidine

Guidance literature:: 4-(4,5-bis(4-methoxyphenyl)thiazol-2-yl)-1-tert-butoxycarbonylpiperidine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With 2-[(4-methylphenyl)sulfonyl]-3-phenyl-oxaziridine; In tetrahydrofuran; hexane; at -78 - 20 ℃;