120-44-5

Basic information

• Product Name: DESOXYANISOIN
• Synonyms: A-(P-ANISYL)-P-METHOXYACETOPHENONE;DESOXYANISOIN;DEOXYANISOIN;4'-METHOXY-2-(P-METHOXYPHENYL)ACETOPHENONE;4'-METHOXY-2-(4-METHOXYPHENYL)ACETOPHENONE;4-METHOXYBENZYL 4-METHOXYPHENYL KETONE;1,2-BIS-(4-METHOXY-PHENYL)-ETHANONE;1,2-Bis(p-methoxyphenyl)ethanone
• CAS NO: 120-44-5
• Molecular Formula: C16H16O3
• Molecular Weight: 256.3
• EINECS: 204-396-8
• Product Categories: Aromatic Ketones (substituted)
• Mol File: 120-44-5.mol
• Article Data: 59

Chemical Properties

• Melting Point: 110-112 °C(lit.)
• Boiling Point: 339.54°C (rough estimate)
• Flash Point: 196.9 °C
• Appearance: white to slightly yellow crystals
• Density: 1.115
• Vapor Pressure: 4.07E-07mmHg at 25°C
• Refractive Index: 1.4500 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility: Sparingly soluble in water.
• BRN: 1536594
• CAS DataBase Reference: DESOXYANISOIN(CAS DataBase Reference)
• NIST Chemistry Reference: DESOXYANISOIN(120-44-5)
• EPA Substance Registry System: DESOXYANISOIN(120-44-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 120-44-5(Hazardous Substances Data)

Usage

Chemical Properties

WHITE TO SLIGHTLY YELLOW CRYSTALS OR CRYST. POWDER

Uses

Deoxyanisoin react to produce a-bromo-4,4'-dimethoxy-deoxybenzoin, and this reaction could happen in the reagent of CCl4 and bromine.

InChI:InChI=1/C16H16O3/c1-18-14-7-3-12(4-8-14)11-16(17)13-5-9-15(19-2)10-6-13/h3-10H,11H2,1-2H3

Upstream product

• 4356-69-8 1,1-bis-(4-methoxyphenyl)ethylene 
• 2132-62-9 4,4'-dimethoxydiphenylacetylene 
• 65850-92-2 2-hydroxy-2,3-bis-(4-methoxy-phenyl)-propionic acid 
• 119-52-8 4,4'-dimethoxybenzoin 
• 105-39-5 chloroacetic acid ethyl ester 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 104-01-8 4-Methoxyphenylacetic acid 
• 100-66-3 methoxybenzene 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 1226-42-2 1,2-bis(4-methoxyphenyl)-1,2-ethanedione 
• 2196-99-8 2-chloro-1-(4-methoxyphenyl)ethanone 
• 67-56-1 methanol 
• 2132-64-1 2,2-bis-(p-methoxyphenyl)-1-bromoethylene 
• 39090-33-0 2,3-bis(p-methoxyphenyl)oxirane 

Downstream Products

• 35258-43-6 α-isopropyldeoxyanisoin 
• 4390-94-7 1,2-bis(4-methoxyphenyl)butanone 
• 1892-36-0 3-dimethylamino-1,2-bis-(4-methoxy-phenyl)-propan-1-one 
• 29149-17-5 1,2-bis-(4-methoxy-phenyl)-3-piperidino-propan-1-one 
• 67295-38-9 1, 2-bis(4-methoxyphenyl)prop-2-en-1-one 
• 102018-51-9 1,2-bis-(4-methoxy-phenyl)-pent-1-en-3-yne 
• 855237-01-3 1,2-bis(4-methoxyphenyl)butan-2-ol 
• 4705-34-4 4,4'-dimethoxystilbene 
• 25457-08-3 1,2-bis-(4-methoxy-phenyl)-pent-1-ene 
• 4705-34-4 1,2-bis(4-methoxyphenyl)ethene 
• 25346-92-3 1,2-bis-(4-methoxy-phenyl)-hex-1-ene 
• 25346-93-4 1,2-bis-(4-methoxy-phenyl)-hept-1-ene 
• 3669-46-3 1-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethanone 
• 36265-54-0 2-(4-methoxyphenyl)-1-(4-methoxyphenyl)ethylamine 

Relevant articles and documents

Silica-supported orthophosphoric acid (OPA/SiO2): preparation, characterization, and evaluation as green reusable catalyst for pinacolic rearrangement

In this paper, we report an easy-to-prepare, cost-effective, efficient, and reusable silica-supported orthophosphoric acid (OPA) catalyst for pinacolic rearrangement. The surface properties of this catalyst were successfully characterized with the help of 31P NMR, TGA, DSC, FT-IR, titration, and microscopy. OPA, hydrogen bonded on the surface, is actually the active species and the reaction seems to occur in the liquid phase embedded in the silica support. As a consequence, the extracting solvent should be chosen with cautious to guarantee the recyclability of the catalyst. As example, pinacol rearrangement reactions were successfully realized with this catalyst and OPA/SiO2 proved to be as efficient as homogeneous orthophosphoric acid to promote the reaction of pinacol derivatives. When using dichloromethane as extracting solvent, OPA/SiO2 can be reuse up to ten times without a significant loss of activity. After ten runs, no physical damage of the catalyst has been observed by microscopy proving its suitability for such application.

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Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25 °C within 40 sec the corresponding aryllithiums which were acylated with various functionalized N,N-

Synthesis and antiseizure activity of (E)-1,2-diarylethylidenehydrazine carboximidamides against tonic-clonic seizures: an intracerebroventricular and electrophysiological study

A series of (E)-1,2-diarylethylidenehydrazine carboximidamides 2a–j were synthesized and characterized by NOESY experiment as anticonvulsant agents and their antiseizure activity was evaluated by intracerebroventricular administration of compounds. Most of the compounds had significant protection against tonic-clonic seizures and 2a was found to be as equipotent as carbamazepine in seizures control. In order to find their anticonvulsant mechanism of action, 2a was subjected to further electrophysiological studies using patch-clamp technique. The results confirmed that this compound is neither a voltage-gated sodium channel blocker nor a NMDA/AMPA antagonist. Although 2a did not show any direct GABA agonistic activity, it could decrease EPSP and increase IPSP frequency without any change in amplitude. Finally, the results indicated most likely a presynaptic GABA-mediated mechanism of 2a for its antiseizure activity such as inhibition of the GABA-T which was validated by molecular docking.