1-(2-(5-(4-(2-chloro-4-nitrophenyl)piperazine-1-carbonyl)-4-methyl-1H-1,2,3-triazol-1-yl)phenyl)ethanone

Base Information

Chemical Name:1-(2-(5-(4-(2-chloro-4-nitrophenyl)piperazine-1-carbonyl)-4-methyl-1H-1,2,3-triazol-1-yl)phenyl)ethanone
CAS No.:1362020-44-7
Molecular Formula:C₂₂H₂₁ClN₆O₄
Molecular Weight:468.9
Hs Code.:

Synonyms:1-(2-(5-(4-(2-chloro-4-nitrophenyl)piperazine-1-carbonyl)-4-methyl-1H-1,2,3-triazol-1-yl)phenyl)ethanone

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Chemical Property of 1-(2-(5-(4-(2-chloro-4-nitrophenyl)piperazine-1-carbonyl)-4-methyl-1H-1,2,3-triazol-1-yl)phenyl)ethanone

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Technology Process of 1-(2-(5-(4-(2-chloro-4-nitrophenyl)piperazine-1-carbonyl)-4-methyl-1H-1,2,3-triazol-1-yl)phenyl)ethanone

There total 3 articles about 1-(2-(5-(4-(2-chloro-4-nitrophenyl)piperazine-1-carbonyl)-4-methyl-1H-1,2,3-triazol-1-yl)phenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.1%

: 1362020-87-8
C₁₂H₁₁N₃O₃

: 114878-60-3
1-(2-chloro-4-nitro-phenyl)piperazine

: 1362020-44-7
1-(2-(5-(4-(2-chloro-4-nitrophenyl)piperazine-1-carbonyl)-4-methyl-1H-1,2,3-triazol-1-yl)phenyl)ethanone

Guidance literature:: C₁₂H₁₁N₃O₃; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

1-(2-chloro-4-nitro-phenyl)piperazine; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h; Cooling with ice;
DOI:10.1021/jm2013503

Reference yield:

: 16714-26-4
1-(2-azido-phenyl)-ethanone

: 1362020-44-7
1-(2-(5-(4-(2-chloro-4-nitrophenyl)piperazine-1-carbonyl)-4-methyl-1H-1,2,3-triazol-1-yl)phenyl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 120 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 3 h / 20 °C / Cooling with ice

With oxalyl dichloride; water; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2013503

Reference yield:

: 1362020-78-7
C₁₄H₁₅N₃O₃

: 1362020-44-7
1-(2-(5-(4-(2-chloro-4-nitrophenyl)piperazine-1-carbonyl)-4-methyl-1H-1,2,3-triazol-1-yl)phenyl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 3 h / 20 °C / Cooling with ice

With oxalyl dichloride; water; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2013503